Research Technician I --- Cancer Center | MGH Institute of Health Professions - Military Veterans

at HERC - New England

Boston, Massachusetts

GENERAL SUMMARY/ OVERVIEW STATEMENT : The Hata Lab in the Massachusetts General Hospital Cancer Center is seeking a highly motivated individual with a strong scientific background for a full-time laboratory research technician position. Research within the Hata Lab focuses on discovering mechanisms of drug resistance in lung cancer patients treated with targeted therapies and developing new therapies to overcome them. We seek to answer pressing clinical questions through patient-centered biological exploration. Our approach prioritizes the use of novel tumor models generated directly from patient tumor specimens for deep mechanistic investigation, with the goal of rapidly translating our laboratory findings into clinical trials. More information about the Hata Lab can be found at: https://hatalab.mgh.harvard.edu. The candidate will assist with basic and translational research projects under the supervision of a post-doctoral research fellow, as well as Dr. Hata (PI). Particular projects include identifying novel drug target for therapy-resistant cancer cells through cutting-edged technologies such as next-generation single cell sequencing, Crispr editing and proteomics. The candidate will learn skillsets in preparing and performing laboratory experiments, assisting with in vivo animal experiments, collection and documentation of procedures and results, analyzing data and assisting with manuscript preparation. This position is ideal for a recent college graduate looking to expand their laboratory research skills in basic/translational research setting and while making contributions to the rapidly evolving field of cancer therapeutics. This opportunity is designed to provide an enhanced experience for prospective graduate (PhD) and medical (MD, MD/PhD) students and provides excellent opportunities for leadership and career development, as well as co-authorship on manuscripts. Previous experience in a cancer research lab, working with mammalian cell culture, or working with mice is not required, however undergraduate research experience in a biologically relevant field is strongly preferred.We are looking for an enthusiastic candidate who is highly motivated, detail-oriented, and works well both independently and on a team. PRINCIPAL DUTIES AND RESPONSIBILITIES: Next generation single-cell RNA and chromatin accessibility sequencing. Crispr based genome or epigenome editing Evaluation and characterization of the sensitivity of cancer cell lines to targeted cancer therapies and the mechanisms of resistance to targeted therapies. Cellular and biochemical techniques including: - Cell viability and apoptosis assays - Western blotting - RNA and DNA purification - Flow cytometry analysis Mammalian tissue culture techniques including cell line maintenance, drug-treatment, cryopreservation, etc. Basic molecular biology including plasmid construction, nucleic acid purification and PCR In vivo evaluation of drug sensitivity in mouse lung cancer models, including establishment of tumor xenografts, drug treatment, assessment of tumor response and harvesting of tumor tissue. Organization and maintenance of written and electronic records of samples, experimental procedures and data generated Generation and interpretation of experimental results; assisting in the preparation and editing of manuscripts resulting from data generated in research projects. Participation in weekly lab meetings and joint translation project meetings with laboratory and clinical project teams Responsibility for ordering common laboratory reagents and general lab maintenance SKILLS/ABILITIES/COMPETENCIES REQUIRED : The Research Technician should also possess: Analytical skills and the ability to resolve problems Ability to interpret acceptability of data results Attention to detail in experimental techniques and record-keeping Working knowledge of data management programs Excellent verbal and written communication skills Capable of working independently and as part of a team Qualifications EDUCATION: Bachelors of Science or similar degree in biological science EXPERIENCE: Prior laboratory research experience with demonstrated competence in research techniques and methodologies Evidence or prior demonstration of leadership and organizational skills Proficiency in Microsoft Word, Powerpoint, and Excel Proficiency in bioinformatic language in Linux, R or Python is preferred. EEO Statement Massachusetts General Hospital is an Equal Opportunity Employer. By embracing diverse skills, perspectives and ideas, we choose to lead. Applications from protected veterans and individuals with disabilities are strongly encouraged.Partner's Healthcare is acting as an Employment Agency in relation to this vacancy.

Boston, Massachusetts

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