Post Doctoral Research Opportunities | Albert Einstein College of Medicine - Military Veterans

at HERC - Metro New York & Southern Connecticut

Bronx, New York

POSITION RESPONSIBILITIES LIST OF POST DOCTORAL RESEARCH CAREER OPPORTUNITIES: When applying, please make sure to reference the number that corresponds to the job posting you are interested in. Department Name : CELL BIOLOGY The research in the Guo lab focuses on stem cell plasticity and epigenetic regulation of mammary stem cells and cancer stem cells, as well as the impact of stem cell pathways on turmor immune microenvironment. We use a wide range of genomics/epigenomics methods, CRISPR genome editing, organoid culture, and in vivo mouse models. Contact email: wenjun.guo@einsteinmed.edu Reference Number EINSTEIN PD 1 Department Name : GENETICS The Zhou lab research focuses on molecular mechanisms of cardiovascular development. Areas of interest include genetic and epigenetic basis of cardiac cell specification and differentiation during development, heart disease, and regeneration ( Cell, 23178125; Nature, 29743679, 25119045, 20596014; Eur Heart J, 26491108; Circ Res, 21597012; Nat Commun, 28924218, 29215012; PNAS, 25848038; Dev Cell, 29056552, 25625206; Annual Review Physiology, 27959615). Contact email: bin.zhou@einsteinmed.edu Reference Number EINSTEIN PD 2 Department Name : NEUROSCIENCE The Ross lab studies neural circuit mechanisms governing the interaction of stress with fundamental motivated behavior, specifically focusing on the mechanisms of neuromodulators and hormones involved in dynamic homeostatic processes. We are interested in how these processes may underlie diseases of metabolism and mental health such as obesity or anorexia nervosa. Prior experience in at least one of these technical areas of expertise is preferred: calcium imaging/ in vivo photometry, mouse behavioral tasks, molecular biology, high dimensional analyses of neuronal data (or biological data in general), electrophysiology, 2-photon microscopy, computer programming and electronics. For more information, please see: https://rosslab.einsteinmedneuroscience.org/research/. Contact email: Rachel.ross@einsteinmed.edu Reference Number EINSTEIN PD 3 Department Name : GENETICS Our research is focused on molecular mechanisms of cardiomyopathy and heart failure. Specific areas of interest include genetic, epigenetic, and long noncoding RNA mechanisms of gene regulation (myocytes, endothelial cells, and fibroblasts) and cardiomyopathy. Our relevant publications include Nature (PMID: 25119045; 20596014; 25119037; 20130577), Cell (15339668); Circulation Research (18723445; 21293009), PNAS (23319608; 27601681), Nature Comm. (28924218; 29215012), Developmental Cell (23602386; 20816797), Annual Review Physiology (22035349), and Nature Review Cardiology (25855606). Contact email: chingpin.chang@einsteinmed.edu Reference Number EINSTEIN PD 4 Department Name : Bronx-Einstein Training in Teaching and Research (BETTR) program The IRACDA-BETTR NIH-sponsored postdoctoral training program is designed to help postdocs obtain tenure-track faculty positions and emphasizes training in research and mentored undergraduate teaching. Our teaching partners are Lehman College and Hostos Community College, two Hispanic-serving colleges located in the Bronx.This three year program provides 75% support for research activities and 25% for mentored teaching. Per NIH criteria, applicants must be U.S. citizens or Green Card holders, and must be within their first two years of postdoctoral training. For more information, see IRACDA/BETTR on the Einstein homepage. Contact email: barbara.birshtein@einsteinmed.edu and/or dianne.cox@einsteinmed.edu Reference Number EINSTEIN PD 5 Department Name : NEUROSCIENCE The Batista-Brito lab investigates how postnatal development of inhibitory function shapes the way information is processed in the brain in the context of health and disease. Cortical function depends on the adaptive function of brain areas comprised of many types of cells and synaptic connections that develop on a long timescale. During development, neural networks must grow from a state of zero connectivity to the precisely interconnected circuits characteristic of the adult brain. The activity of GABAergic inhibitory neurons during postnatal development is likely to mediate synaptic refinement, reducing synchrony and enhancing precision in the mature network. Accordingly, dysregulation of GABAergic interneurons has been linked to several neurodevelopmental disorders. We use a powerful combination of methods, including single-cell genetic profiling, mouse genetics, cell-type specific manipulation of neuronal activity, in vivo electrophysiology, in vivo 2-photon imaging, and behavioral analysis, in order to functionally dissect the developmental impact of specific sources of inhibition on cortical processing and perception. This research illuminates how cortical functions are altered in neurodevelopmental disorders, with particular focus opn schizophrenia and autism. Contact email: renata.brito@einsteinmed.edu Reference Number EINSTEIN PD 6 Department Name : ANATOMY AND STRUCTURAL BIOLOGY The Verkhusha lab is interested in the development and application of molecular probes, such as biosensors and optogenetic tools, for monitoring and controlling biological processes in cells and animals. Two postdoctoral positions are available A: A molecular biologist interested in engineering fluorescent protein-based biosensors and characterizing them both in vitro and in cultured cells. B: A neuroscientist interested in imaging with advanced biosensors for the optogenetic control of activity and molecular processes in neurons, as well as cellular electrophysiology, electric field stimulation, optogenetics and calcium imaging. Contact email: vladislav.verkusha@einsteinmed.edu Reference Number EINSTEIN PD 7A or 7B Department Name : BIOCHEMISTRY Postdoctoral positions in Translational Chemical Biology available in the Gavathiotis Laboratory at Albert Einstein College of Medicine, New York City. Our laboratory focuses on understanding mechanisms and protein signaling in cell death and cell survival pathways such as mitochondrial regulated cell death, autophagy and RTK/RAS/ERK signaling. Our goal is to characterize novel biological mechanisms and validate novel targets that contribute to cancer and other diseases. Using structural, computational, and chemical strategies we harness mechanistic insights to discover first-in-class chemical probes and develop novel therapeutics that enable translational applications. Postdoc scientists will be involved in developing novel platforms and therapeutic strategies based on BCL-2 family proteins, mitochondrial membrane proteins or protein kinases.We seek motivated and ambitious candidates, with a strong record of accomplishments, and a Ph.D. or experience in either of these areas: chemical biology, biochemistry, structural biology, molecular biology, cell biology, pharmacology. Experience in relevant signaling pathways, structural, chemical, proteomic, genetic and chemical screening technologies will be further appreciated depending on the project. We offer an opportunity to work with a multidisciplinary group using chemical biology, structural biology, biochemistry, cell biology, computational and experimental screening, medicinal chemistry, drug design and in vivo pharmacology. Our lab provides an environment that fosters creativity, innovation and collaboration aiming for fundamental and translational discoveries. Please see more details of research interests and publications of the Gavathiotis group https://einsteinmed.edu/faculty/12958/evripidis-gavathiotis/ . Applicants should send a cover letter, including a summary of past and present research interests and accomplishments, and a curriculum vitae with names and contact details of three references. Please send your application or any specific questions to Dr. Evris Gavathiotis, Professor of Biochemistry and Medicine at the Albert Einstein College of Medicine Contact email: evripidis.gavathiotis@einsteinmed.edu Reference Number EINSTEIN PD 8 Department Name : NEUROSURGERY The Eskandar lab studies cortical-subcortical circuits and their role in learning, decision-making, and addiction. We perform micro-electrode recordings and micro-stimulation in experimental animals performing a variety of cognitive tasks and in humans performing parallel tasks, while implanted with electrodes for the treatment of Parkinson disease or epilepsy. This translational approach supports our over-arching goal of developing novel neuro-modulatory therapies for patients suffering from cognitive impairment, substance or behavioral addictions, and other neuropsychiatric disorders. Contact email: eskanda@montefiore.org Reference Number EINSTEIN PD 9 Department Name : MEDICINE and MICROBIOLOGY AND IMMUNOLOGY A position is open for the study of human protective antibodies against M. tuberculosis. This will be especially of interest for applicants who want to expand or gain experience in translational research. Specific interests of the laboratory include understanding the role of antibodies to M. tuberculosis in patients at various states of infection. These include i) large scale tuberculosis serology studies using innovative techniques to identify both antibodies that can serve as tuberculosis biomarker as well as antibodies with protective functions, ii) isolation and generation of polyclonal and monoclonal human antibodies to M. tuberculosis antigens, and iii) detailed studies of antibody mechanism against M. tuberculosis in vitro and in vivo . Candidates should have a strong background in Immunology and/or Microbiology. Contact email: Jacqueline.Achkar@einsteinmed.edu Reference Number EINSTEIN PD 10 Department Name : NEUROLOGICAL SURGERY We aim to engineer treatments for disorders of visuospatial learning and memory. To achieve this aim, we perform studies to better our understanding of visuospatial learning and memory functions. We utilize advanced electrophysiological techniques to examine the circuitry of brain structures that are critical for these functions. Contact email: nathaniel.killian@einsteinmed.edu Reference Number EINSTEIN PD 11 Department Name : NEUROSCIENCE The Castillo lab studies how neural activity controls the strength of synaptic connections in the brain -- a process known as synaptic plasticity -- and how dysregulation of this process contributes to brain disease states. To this end, we use a combination of experimental approaches, including electrophysiology, optogenetics, two-photon laser microscopy, in vivo calcium imaging, behavioral analyses, and a wide-range of molecular approaches to probe and manipulate specific neural circuits. A postdoctoral position is immediately available to investigate how experience in the form of learning paradigms leads to long-term changes at hippocampal synapses. Prior expertise in any of the following experimental approaches is a plus: electrophysiology, in vivo recordings/calcium imaging, computer programming and rodent behavioral tests. For more information, see: https://www.einstein.yu.edu/faculty/8363/pablo-castillo/ and https://einstein.pure.elsevier.com/en/persons/pablo-e-castillo Contact email: pablo.castillo@einsteinmed.edu Reference Number EINSTEIN PD 12 A As member of the Rose F. Kennedy Intellectual and Developmental Disabilities Research Center (IDDRC), the Castillo lab is investigating how loss of function in Fragile X Mental retardation protein (FMRP), which causes Fragile X Syndrome (FXS), alters synaptic structure and function. A postdoctoral position is immediately available to investigate the role of FMRP at excitatory and inhibitory synapses both in the normal brain and in an animal model of FXS. Prior expertise in electrophysiology, molecular biology and confocal microscopy is a plus. For more information, see: https://www.einstein.yu.edu/faculty/8363/pablo-castillo/ and https://einstein.pure.elsevier.com/en/persons/pablo-e-castillo Contact email: pablo.castillo@einsteinmed.edu Reference Number EINSTEIN PD 12B Department Name : NEUROSCIENCE The Jordan Lab recently identified patients around the world presenting with a spectrum of neurodevelopmental phenotypes, including autism, speech apraxia, and intellectual disability, and which is caused by monogenic deletions of the ANKS1B gene. ANKS1B encodes for AIDA-1 protein, a highly abundant component of neuronal excitatory synaptic junctions that regulates NMDA receptor (NMDAR) function. A position is available to use animal and human models to analyze NMDAR in patient neurons, elucidate mechanisms linking AIDA-1 to NMDAR function, and identify disease-relevant cellular and molecular pathways underlying this novel disorder. Contact e-mail: bryen.jordan@einsteinmed.edu Reference Number EINSTEIN PD 13 Department Name : PEDIATRICS The Department of Pediatrics at Einstein and Children's Hospital at Montefiore (PI: Marina Reznik, MD, MS) is looking for a postdoctoral research fellow to collaborate on population-based studies of childhood asthma. Examples of several current studies include implementation and evaluation of a multi-level clinic-based intervention to improve provider adoption of asthma guidelines and patient outcomes; cluster RCT of a school-based study of asthma management program; and cross-sectional study of provider prescription practices and pharmacy availability of spacer devices for asthma. The Postdoctoral Research Fellow will develop new scientific hypotheses and research questions to be addressed using data from existing datasets from clinical trials, including commonly available national datasets; conduct statistical analyses and draft manuscripts, reports and presentations; assist with grant applications; and oversee other ongoing clinical studies and research staff. Contact email: mreznik@montefiore.org Reference Number EINSTEIN PD 14 Department Name : NEUROSCIENCE The Laboratory for Computational Neuroscience (Coen-Cagli lab) invites applications for a postdoctoral position in the Department of Systems and Computational Biology and Department of Neuroscience at Albert Einstein College of Medicine. Our lab studies sensory processing in brains and machines. We study probabilistic representations of natural images, to understand visual perception and neural activity in visual-cortical populations. We combine theories of probabilistic neural coding, computer vision and machine learning algorithms, perceptual experiments, and primate and rodent neurophysiology through collaborations. Lab website: https://sites.google.com/site/rubencoencagli Contact email: Ruben.coen-cagli@einsteinmed.edu Reference Number EINSTEIN PD 15 Department Name : MICROBIOLOGY AND IMMUNOLOGY Our laboratory utilizes innate immune factors to study HIV-1 uncoating, reverse transcription and nuclear import (PMID: 32997983 and 32187548). To investigate these HIV-1 steps, we utilize virology, cell biology, biochemistry, immunology and mouse biology. We also pursue the development of therapeutics for emergent infectious viruses such as ZIKA and SARS-CoV-2 (PMID: 31501074). Contact email: Felipe.Diaz-Griffero@einsteinmed.edu Reference Number EINSTEIN PD 16 Department Name : NEUROSCIENCE The Kurshan Lab (www.kurshanlab.org) uses the nematode C. elegans to investigaes how synapses are built. The genetic and optical accessibility of the worm, combined with its sterotyped development, make it an ideal system in which to interrogate the molecular underpinning of synapse development. Using this model, we investigate how mutations in synaptic genes linked to neurodevelopmental disorders such as autism and schizophrenia contribute to the normal function of the synapse. Contact email: Peri.kurshan@einsteinmed.edu Reference Number EINSTEIN PD 17 Department Name : SYSTEMS AND COMPUTATIONAL BIOLOGY A postdoc positions are open for developing and employing computational techniques for designing specificity for protein interfaces in various disease-oriented applications. The research includes various aspects of method development to analyze, predict and design protein interfaces. The position is highly interdisciplinary and provides close collaborations with experimentalists with follow up translational applications. The ideal candidate holds a PhD degree in relevant fields (e.g. computational biology, chemistry, physics, applied mathematics) and has an extensive computational background in scripting and programming languages, familiar with Linux operating system. Has a strong working knowledge of principles of protein structures, familiar with bioinformatics programs and applications, including some experience with MD simulations. Contact email: Andras.fiser@einsteinmed.edu Reference Number EINSTEIN PD 18 Department Name : BIOCHEMISTRY, MEDICINE AND OBSTETRICS & GYNECOLOGY AND WOMEN'S HEALTH The Charron Laboratory is interested in understanding the molecular basis of early life exposures that predispose offspring to metabolic disease and/or developmental disabilities. Our Bronx MomBa Study on babies recruited at birth and followed through 24 months of age for early childhood obesity and developmental delay inorporates molecular epigentic, transcriptomic, and functional assessments of immune cells and interactions with the metabolome and gut microbiome. We use mouse models to rigorously test dietary and therapeutic interventions for the ability to modify the developmental environment and provide life long improvements in metabolic and behavioral outcomes in offspring. Contact email: Maureen.charron@einsteinmed.edu Reference Number EINSTEIN PD 19 Department Name : RADIOLOGY Our research focuses on applying medical imaging methods and analysis methods (include machine learning) to study health and disease, aiming at early detection, accurate diagnosis, evaluation and prediction of disease courses and treatment responses. We collaborate closely with clinicians to solve clinically impactful problems. Some of projects include: i) Effects of chemotherapy on neurocognitive function in cancer patients, ii) MRI studies of breast cancer and lymph node metastasis and treatment response, iii) MRI study of neurodegenerative disease and acquired brain injuries, and iv) COVID-19 and COVID-19 sequela. https://sites.google.com/view/duong-lab/ Contact email: Tim.duong@einsteinmed.edu Reference Number EINSTEIN PD 20 Department Name : NEUROSCIENCE AND GENETICS AND STEM CELL INSTITUTE The Hebert lab is developing protocols for repairing the adult neocortex when it is damaged due to disease or aging. In one set of projects, the lab studies how donor cell populations comprised of multiple subtypes can recapitulate normal tissue cytoarchitecture when transplanted in layers. In another set of projects, the lab is studying how transplanted microglia can be used as a delivery vehicle for biologics to treat neurodegeneration. For more info, please visit: https://hebertlab.einsteinmedneuroscience.org/ Contact email: Jean.hebert@einsteinmed.edu Reference Number EINSTEIN PD 21 Department Name : NEUROSCIENCE AND OTORHINOLARYNGOLOGY A joint postdoctoral research fellow position is available in the Departments of Neuroscience and Radiology. Using brain electrophysiology (EEG) and neuroimaging (fMRI) techniques, our newly-funded NIH project is investigating chronic effects of chemotherapy treatment on brain development and cognitive functioning in childhood leukemia survivors (ages 5-12 years). Contact email: elyse.sussman@einsteinmed.edu & mark.wagshul@einsteinmed.edu Reference Number EINSTEIN PD 22 Department Name : CELL BIOLOGY Alphaviruses are enveloped RNA viruses that include important human pathogens such as Chikungunya virus. We have developed robust multidisciplinary tools to characterize the molecular interactions and mechanisms of virus and host cell components during the virus lifecycle. Many important questions remain unsolved, and current research projects include the study of virus assembly, trafficking, budding, and cell-to-cell transmission. A new project will address the development of antiviral therapies. Contact email: margaret.kielian@einsteinmed.edu Reference Number EINSTEIN PD 23 Department Name : GENETICS The Lachman lab uses induced pluripotent stem cell (iPSC) technology to model intellectual disabilities and autism. Both patient-specific and CRISPR-Cas9 gene edited lines are used. These are differentiated in various neuronal cell types and cerebral organoids, the latter of which is used as a model for early brain development. RNA sequencing and phosphoproteomics are carried out to help understand the underlying molecular basis of these conditions and to identify druggable targets for therapeutic intervention. Contact email: herb.lachman@einsteinmed.edu Reference Number EINSTEIN PD 24 Department Name : GENETICS AND PEDIATRICS Join our childhood cancer research team and focus on an exciting new opportunity to evaluate novel approaches to inhibiting telomere maintenance mechanisms. Apply your cellular and molecular biology skills, learn bioinformatics, and see real-time results translate into the next clinical research study for relapsed neuroblastoma. We value teamwork, integrity, ambition, and intellectual curiosity (https://www.einsteinmed.org/faculty/13846/daniel-weiser/) Contact email: daniel.weiser@einsteinmed.edu Reference Number EINSTEIN PD 25 Department Name : GENETICS The Verkhusha laboratory at the Albert Einstein College of Medicine https://www.einstein.yu.edu/faculty/10316/v...slav-verkhusha/ is looking for postdocs interested in development and applications of genetically encoded biosensors and optogenetic tools for monitoring and control of biological processes in cells and animals. Current projects focus on engineering of fluorescent biosensors for imaging of neuromodulators, neurotransmitters, enzyme activities, coupled with optogenetics. In addition to molecular biologists, we are looking for a neuroscientist willing to couple imaging with advanced biosensors to optogenetic control of activity and molecular processes in neurons, using cellular electrophysiology, electric field stimulation, optogenetics and calcium imaging. Contact email: vadislav.verkhusha@einsteinmed.edu Reference Number EINSTEIN PD 26 Department Name : MICROBIOLOGY & IMMUNOLOGY Kalpana Laboratory studies molecular mechanisms of HIV-1 replication, HIV-1 latency and Cancer and use this information to develop novel therapeutic and diagnostic strategies for AIDS and Cancer. By investigating the structure-function analysis, protein-protein and protein-RNA interactions of INI1/SMARCB1, a tumor suppressor and a host factor that binds to HIV-1 integrase, we have discovered that structural mimicry of proteins to RNA that has led to the development of novel therapeutic strategies for HIV-1. Furthermore, by applying state-of-the art technologies including single molecule RNA-FISH and single cell RNA-seq, we are studying HIV-1 latency and SARS-CoV2 replication. Contact email: ganjam.kalpana@einsteinmed.edu Reference Number EINSTEIN PD 27 Department Name : CELL BIOLOGY The Pamela Stanley lab identifys specific roles for gylcans during spermatogenesis . The Stanley lab has shown that MGAT1 and complex N-glycans are essential for spermatogenesis. Conditional deletion of Mgat1 in spermatogonia results in spermatid fusion and no sperm. Roles for specific glycoproteins in the spermatogenesis defect will be investigated. Publications are linked to the laboratory homepage at http://www.einstein.yu.edu/departments/cell-biology/faculty/stanley/home/ Contact email: gianette.fata@einsteinmed.edu Reference Number EINSTEIN PD 28 Department Name : NEUROSCIENCE & PEDIATRICS (NEONATOLOGY) The Ballabh laboratory is seeking highly motivated, successful, and creative individual(s) with a background in neuroscience. The post-doctoral fellow will be participating in translational research on animal models of intraventricular hemorrhage (IVH) of prematurity. The main focus of our laboratory is to study underlying mechanisms and developing novel therapies for prematurity- and IVH-induced brain injuries. We employ a multidisciplinary approach and integrate histology, neuroimaging, genomics, MRI and neurobehavioral studies to answer our research question. Please see our lab website for more information: https://ballabhlab.einsteinmedneuroscience.org/ Contact email: praveen.ballabh@einsteinmed.edu Reference Number EINSTEIN PD 29 Department Name : CELL BIOLOGY A postdoctoral position is available at Albert Einstein College of Medicine in the laboratory of Dr. Art Skoultchi, Professor and Chair of Cell Biology. The goal is to understand the roles of H1 linker histones in chromatin structure and function, gene regulation and cancer. We have prepared a unique series of knock-out mice and ES cell lines lacking specific H1 histones. Our studies have revealed roles for H1 histones in gene regulation, the epigenetic landscape and nuclear organization. Contact email: arthur.skoultchi@einsteinmed.edu Reference Number EINSTEIN PD 30 Department Name : GENETICS Laboratory of Dr. Masako Suzuki, DVM, PhD A postdoctoral position in the area of Developmental Origins of Health, lineage commitment of stem cells, transcription, signaling, developmental biology, genomics, and bioinformatics. The research projects are focused on how the offspring remembers the exposure status of maternal micronutrient deficiency in the uterus and how it links to the disease risks of offspring later in life. Contact email: masako.suzuki@einsteinmed.edu Reference Number EINSTEIN PD 31 Department Name : INSTITUTE FOR AGING RESEARCH Laboratory of Drs. Nir Barzilai, Sofiya Milman, and Zhengdong Zhang A multidisciplinary group of researchers that aims to understand the biological mechanisms of healthy aging in human cohorts enriched for longevity is seeking postdoctoral fellows to join their team at Einstein's Institute for Aging Research, a leading institution in human aging research, headed by Nir Barzilai, M.D. Einstein is home to the Nathan Shock Center of Excellence in the Basic Biology of Aging and the Paul F. Glenn Center for the Biology of Human Aging. We offer a stimulating, supportive, and collaborative environment for candidates with an interest in the biology of aging and multi-omics. The candidate will have access to genomic, proteomic, metabolomic, and clinical datasets, as well as samples from Einstein's familial longevity studies. Recent NIH-funded projects include discovery of resilience mechanisms to Alzheimer's disease and biological regulation of pathways implicated in longevity. Drs. Nir Barzilai, Sofiya Milman, and Zhengdong Zhang are looking for innovative, motivated candidates, who can work independently but also collaborate closely with clinical, basic and computational researchers. Applicants will be expected to apply and develop computational tools to model and address questions in human biology and aging. T32 funding is available and transition to a faculty position is possible. The group has a strong track record of mentoring early career scientists in obtaining career development awards and transitioning to research independence. Additional information about the Institute can be found at https://einsteinmed.org/centers/aging/. Contact email: nir.barzilai@einsteinmed.edu & sofiya.milman@einsteinmed.edu Reference Number EINSTEIN PD 32 Department Name : BIOCHEMISTRY Laboratory of Dr. David Shechter, PhD A Postdoctoral position is available in the Shechter Laboratory (www.shechterlab.org) to investigate the role of protein arginine methyltransferases (PRMTs) in genome and splicing regulation. The research projects are focused on biochemical mechanisms of substrate recognition and methylation by PRMTs, including characterizing enzymological parameters, identification and characterization of novel methylarginine effector proteins, and/or cellular or biological consequences of these enzymes' activities. Contact email: david.shechter@einsteinmed.edu Reference Number EINSTEIN PD 33 Department Name : INFECTIOUS DISEASES Laboratory: Dr. Johanna Daily The Daily lab is hiring a post-doctoral fellow to study brain swelling in the experimental model of cerebral malaria (ECM). We are seeking a highly motivated and productive scientist to lead the program which will define mechanisms of brain swelling through analysis of gene knock out of parasite virulence proteins, metabolomics, histopathology and neuroimaging. Adjunctive therapies will be tested in vivo to improve survival in ECM. The scientist will be expected to design and conduct experiments, interpret data and prepare manuscripts. Funding is available for two years, the initial appointment is for one year and will be renewed with satisfactory progress. Contact email: johanna.daily@einsteinmed.edu Reference Number EINSTEIN PD 34 Department Name : PEDIATRICS Our research at the IDDRC Human Clinical Phenotyping Core / Cognitive Neurophysiology Laboratory (cognitiveneurolab.com) is focused on children and adolescents presenting with a diverse range of intellectual and developmental disabilities. Specific areas of interest include NIH-funded studies of children on the autism spectrum, research involving children with typical development, and with individuals with rare diseases such as 22q11.2 deletion syndrome and Cystinosis. The clinical postdoctoral research follow will have familiarity with administration, testing, scoring, and report writing is a plus. Demonstrated experience in working with children and adolescents, including experience working with children with developmental disabilities; experience with children on the Autism Spectrum is a plus. Familiarity with autism diagnostic tools (ADOS-2 and ADI-R) is preferred but not requisite. The individual will be overseen by a licensed clinical neuropsychologist and will receive substantial training and abundant experience in the administration of assessments that constitute our various study batteries. Contact email: rachel.hester@einsteinmed.edu Reference Number EINSTEIN PD 35 Department Name : MOLECULAR PHARMACOLOGY Our research focuses on the cancer cell state transitions that enable persistence to therapy, and on the effect of the 3-dimensional tumor microenvironment on tumor response to pharmacological and immune therapies. The ongoing projects offer the opportunity for acquisition of expertise in a wide range of in vitro/in vivo cancer models (including novel 3D organoid culture and co-culture models) and experimental therapeutics approaches. The position requires self-motivation, excellent organizational abilities and strong hands-on experimental skills. Prior experience with cell culture techniques, drug-response assays, molecular cloning, CRISPR screening, flow cytometry, confocal microscopy and/or animal cancer models are highly desired. Acquisition of familiarity with data analysis software (Excel, GraphPad etc.) and molecular databases is expected. Computational and systems biology knowledge is not essential but would be a plus. Contact email: eugen.dhimolea@einsteinmed.edu Reference Number EINSTEIN PD 36 Department Name : MEDICINE Post-doctoral fellow needed in Spivack laboratory with substantial experience in molecular biology/molecular genetics, to engage in novel functional studies of epigenetic change in human lung carcinogenesis and other airway disorders. Recent state-of-art lung bronchial epithelial progenitor cell somatic analyses are published/in process (Nature Genetics, mutationome) or being assembled (comprehensive methylome). Unique human lung and surrogate tissue repository. Aspects of CRISPR technology experience would be helpful, as would a knowledge of DNA methylation and some background knowledge of ATAC-seq/ChIPseq/RNAseq. Position for one year minimum, likely two or more. Contact email: simon.spivack@einsteinmed.edu ;Karen.milian@einstein.yu.edu Reference Number EINSTEIN PD 37 Department Name : NEUROLOGY The Molero lab focuses on defining the mechanistic underpinnings of Huntington's disease (HD). We are interrogating how HD-mediated deficits in forebrain neurogenesis affecting the generation of interneurons disrupts cortico-striatal periods of neural cell and network plasticity, leading to hyper-connectivity and hyper-excitability. We have hypothesized that this circuit maldevelopment results in the generation of "metastable" cells with lower reserves to cope with various stressor states thereby accounting for Huntington's disease pathogenesis later in life. Contact email: aldrin.molero@einsteinmed.edu Reference Number EINSTEIN PD 38 Department Name : CELL BIOLOGY A postdoctoral position is available in the laboratory of Dr. Satish Nandakumar (www.nandakumarlab.org) at Albert Einstein College of Medicine and Albert Einstein Cancer Center. Research in our laboratory is focused on understanding how germline genetic variants predispose to clonal hematopoiesis and hematologic malignancies. We use approaches at the interface of human genetics, hematopoietic stem cell biology and gene regulation including CRISPR/Cas9 editing and high-throughput genomic screens to address this question. Our recent findings (Bao et al., Nature 2020; Bick et al., Nature 2020) has uncovered a previously unappreciated mechanism for inherited risk of myeloid malignancies involving modulation of hematopoietic stem cell (HSC) function and self-renewal. We are particularly seeking an enthusiastic, committed, friendly individual with experience in hematopoiesis or leukemia research. The position will provide considerable opportunities for intellectual development through dedicated individual mentorship and guidance. Ability and interest to perform bioinformatics analysis is desired but not required. Contact email: satish.nandakumar@einsteinmed.edu Reference Number EINSTEIN PD 39 Department Name: OPHTHALMOLOGY AND VISUAL SCIENCES Inherited retinal degenerations cause blindness that is currently incurable. Research in Liu lab aims to elucidate the mechanisms underlying human retinal differentiation and inherited degenerations using engineered mice and stem cell-derived retinal organoids. Their findings make an impact on the regenerative medicine of the retina. Contact email: wei.liu@einsteinmed.edu Reference Number EINSTEIN 40 Department Name: CELL BIOLOGY Postdoctoral position available to study the roles of H1 linker histone in epigenetic marking and 3D organization of mammalian chromatin. Lab of Dr. Art Skoultchi, Professor and Chair, Department of Cell Biology. See Willcockson et al. Nature 589:293 (2021) - https://pubmed.ncbi.nlm.nih.gov/33299182/ Contact email: arthur.skoultchi@einsteinmed.edu Reference Number EINSTEIN PD 41 Department Name: CELL BIOLOGY The Stengel lab is interested in understanding the mechanism by which oncogenic transcription factors alter gene expression networks to drive tumorigenesis. We combine cutting edge technologies including CRISPR-based genome editing, degradation of endogenous proteins, functional genomics and mass spectrometry to comprehensively define transcription factor regulatory networks and mechanisms of control. Contact email: kristy.stengel@einsteinmed.edu Reference Number EINSTEIN PD 42 Department Name: BIOCHEMISTRY The research in the Gennerich Lab is focused on the molecular functions of the microtubule motors kinesin and cytoplasmic dynein (molecular machines that harness the chemical energy of ATP hydrolysis to perform mechanical work in eukaryotic cells), the regulation of RNA polymerase II-based transcription elongation through nucleosomes, and the molecular mechanism of transcription elongation by RNA polymerase III. Contact email: arne.gennerich@einsteinmed.edu Reference Number EINSTEIN PD 43 Department Name : MEDICINE, EPIDEMIOLOGY AND GENETICS Distillation of 'omics level surveys of somatic mutation, methylome, and transcriptomes of lung tissue and tumors are being evaluated for (i) evaluation of functional consequences and (ii) translation to non-invasive exhaled and exfoliated biomarkers of risk for lung cancer, asthma, COPD. Contact email: Simon.Spivack@einsteinmed.edu Reference Number EINSTEIN PD 44 Department Name: MOLECULAR PHARMACOLOGY We are looking for motivated fellows to work on the mechanism of mRNA translation in pancreatic cancer. A strong background in cancer biology and signal transduction is desired. A perfect candidate will have experience in mouse modeling, molecular biology, and willingness to learn and develop new technology and tools to advance cancer research. For more information check our lab webpage. https://kaminiy79.wixsite.com/mysite https://einsteinmed.edu/faculty/17030/kamini-singh/ Contact email: kamini.singh@einsteinmed.edu Reference Number EINSTEIN PD 45 Department Name: GENETICS The Dawlaty Lab at Albert Einstein College of Medicine is seeking postdoctoral fellows to investigate the epigenetics of stem cells, development and cancer. We are applying biochemical, molecular, developmental and bioinformatics approaches to define epigenetic mechanisms that regulate the biology of embryonic, hematopoietic and neural stem cells. We establish their biological relevance in normal development and in human developmental disorders and cancer. Contact email meelad.dawlaty@einsteinmed.edu Reference Number EINSTEIN PD 46 Department Name: NEUROLOGY This work will focus on cognitive aging and dementia in a population study of older adults. The research will involve the analysis of neurocognitive, epidemiological and biomedical data from multiple sources including conventional neurocognitive tests, neurocognitive tests administered at home using tablets and smart-phones as well tests administered by telephone. Risk factors are assessed by multiple ambulatory devices. It is expected that the candidate will supervise psychological tests administered by research staff, attend case conferences and weekly research meetings. It is expected this approach will develop an independent line of investigation and the candidate will participate with one or more research teams studying areas of interest to the candidate. Our research group involves multiple faculty members with expertise in neuropsychology, clinical neurology, biostatistics, epidemiology, biomarkers, neuroimaging, diabetes, sleep medicine, pain and stress. The candidate will be co-mentored by faculty with the appropriate expertise depending upon the project or projects he/she will work on. Contact email: Mindy.Katz@einsteinmed.edu Reference Number EINSTEIN PD 47 Department Name: GENETICS Nicholas Baker Lab: Postdoctoral position studying cell competition Cell competition recognizes and eliminates abnormal cells during development, and is thought to be important in aging and cancer[1]. Our group has identified the cell competition pathway that responds to and eliminates aneuploid cells, on the basis of altered ribosomal protein gene dose. Postdocs will employ multidisciplinary genetic, molecular genetic, biochemical, and imaging approaches to characterize cell competition in flies and/or mice. 1. Baker, N.E. Emerging mechanisms of cell competition. Nature Reviews Genetics, 2020 21 : 683-697. PMID: 32778819 Contact email: Nicholas.baker@einsteinmed.edu Reference Number EINSTEIN PD 48A Nicholas Baker Lab: Postdoctoral positions studying neural development Proneural bHLH transcription factors are master regulators of neural cell fate determination and differentiation and important components of neuronal reprogramming strategies in mammals[1]. We will use Drosophila eye development to identify and characterize novel regulators of proneural bHLH proteins, in a multidisciplinary approach that may involve developmental genetic studies, protein biochemistry, and genetic screens coupled to modern whole-genome sequencing approaches. 1. Baker, N.E. and N.L. Brown, All in the family: neuronal diversity and proneural bHLH genes. Development, 2018. 145 : p. dev159426. Contact email: Nicholas.baker@einsteinmed.edu Reference Number EINSTEIN PD 48B Department Name: MOLECULAR PHARMACOLOGY The Hodgson lab studies the role of Rho family of small GTPases on cell motility. We develop monomeric, single-chain Forster resonance energy transfer (FRET)-based biosensors to address biological questions surrounding cancer invasion and metastasis, immune cell chemotaxis and motility, vesicular trafficking, and many other general actin cytoskeleton dynamics regulated by Rho family small GTPases. We emphasize hypothesis-driven, classical cell biology research in our laboratory in a variety of disease relevant areas. Contact email louis.hodgson@einsteinmed.edu Reference Number. EINSTEIN PD 49 Department Name: ONCOLOGY The Kuang Lab studies the biology and therapeutics for colon cancer and other GI cancers. We use wet-lab techniques such as tissue culture, patient derived organoids, and xenograft models to test and validate novel therapies and targets. We will also use multi-omic analysis of clinical specimens to discover novel targets for treatment. Contact email: Chaoyuan.kuang@einsteinmed.edu Reference Number EINSTEIN PD 50 Department Name: PEDIATRICS The world-class Burk lab is seeking a highly motivated applicant with optimism, patience, idealism and courage to join our team. We investigate the molecular epidemiology of HPV and the human microbiome using large population-based clinical samples and study data. The lab focuses on translational questions combining epidemiology, NGS, bioinformatics and molecular-genetic approaches to push the envelope. Lab motto: We develop potential and the science will follow. Contact email: robert.burk@einsteinmed.edu Reference Number EINSTEIN PD51 Department Name: CELL BIOLOGY Our lab uses state-of-the-art epigenomic approaches to examine gene regulatory programs that drive cellular diversity in lung cancer. To do this, we use lung cancer modeling strategies to study chromatin biology with the overarching goal of better understanding and targeting mechanisms of lung cancer progression. These methods include the use of single-cell ATAC-sequencing and related chromatin profiling techniques, murine modeling, and lung organoids. Contact email: lindsay.lafave@einsteinmed.edu Reference Number. EINSTEIN PD 52 Department Name: MOLECULAR PHARMACOLOGY Postdoctoral positions available in Dr. Cai's lab are to develop research on fundamental questions in understanding the neural and immunological basis of aging, metabolic syndrome (obesity, diabetes and hypertension), brain cancer and neurodegenerative disease, with innovative approaches in stem cells, RNA biology, neuroinflammation, epigenetics (DNA methylation), and computational science. Cai's lab has strong tradition and track record in generating breakthrough research in these areas. Contact email: dongsheng.cai@einsteinmed.edu Reference Number EINSTEIN PD 53 Department name: CARDIOLOGY The Department of Cardiology is looking for a postdoctoral research fellow to collaborate in population-based studies of cardiovascular disease, cardiac structure, cardiac function and diabetes, neurocognitive functioning, social determinants of health, and cardiometabolic risk. Emphasis of the program is in cardiovascular epidemiology integrating biological, psychological, social, and ethnic/racial as well as cultural levels of analysis using data from our existing cohorts mainly the Hispanic Community Health Study (HCHS) but also including MESA, CARDIA, ARIC, FHS, CHS and JHS. The Postdoctoral Research Fellow will work closely with Dr. Carlos Jose Rodriguez, Professor of Cardiology and Epidemiology and Population Health and co- Investigator of the HCHS, as well as with other Investigators in the Depart of Epidemiology and Population Health. Develop new innovative scientific hypotheses and research questions to be addressed using the existing cohort data as well as other projects based in the Depart of Epidemiology and Population Health. The Postdoctoral Fellow will have primary responsibility for developing innovative ideas for manuscripts and data analyses in HCHS and other study cohorts with support and advice form the Principal Investigator, other co-investigators and biostatisticians. The Postdoctoral Research Fellow will conduct statistical analyses in collaboration with faculty, biostatisticians and staff-level data analyses. Attend conferences to present study results and to meet with collaborators at other study sites. Contact email: carlos.rodriguez@einsteinmed.edu Reference Number: PD 54 Department Name: BIOCHEMISTRY A position for a PostDoc is available immediately in the Cowburn lab at Albert Einstein College of Medicine, focused on NMR based structural biology. Areas of focus are characterization of interactions of intrinsically disordered systems in selective transport in the nuclear pore (Hough et al., 2015; Raveh et al., 2016; Sparks et al., 2020; Sparks et al., 2018) and protein engineering applications and basic mechanisms of inteins (Eryilmaz et al., 2014; Stevens et al., 2018; Stevens et al., 2017) In addition the these focal areas, the lab has extensive NMR related collaborations e.g. (Dixit et al., 2021; Warren et al., 2017). The successful candidate will benefit from access to outstanding resources in NMR and X-ray crystallography including a SampleJet autosampler, robotic dispensers for NMR sample preparation and crystallization, protein production facilities (E. coli, baculovirus and mammalian cells), biophysical analysis (MST, FP, ITC, SPR, DLS), proteomics, plus Linux clusters and use of XSEDE for computational modeling and calculations. Our laboratory has access to high-field NMR including two modern in house 600 MHz NMR spectrometers, two 900 MHz and three 800 MHz spectrometers at the New York Structural Biology Center (NYSBC). NYSBC also provides access to additional resources in X-ray crystallography, and Cryo-electron microscopy. Resources at National Labs are available for SAXS and SANS. Contact email: david.cowburn@einsteinmed.edu Reference Number: EINSTEIN PD 55 Department Name: INTEGRATIVE STRUCTURAL AND COMPUTATIONAL BIOLOGY The Kitamura laboratory at the Albert Einstein College of Medicine (skitalab.com) is looking for postdoctoral researchers interested in development and applications of small molecule chemical probes and therapeutics (multiple positions available). We employ a multidisciplinary approach to target emerging infectious pathogens, cancer, microbiome and metabolic diseases. The successful applicant will have deep knowledge of, and strong technical skills and a proven track record in the following area: Synthetic or medicinal chemistry, chemical biology: Synthetic organic chemistry, compound purification, and structural characterization, with profound literature search skills, the ability to design and improve synthetic routes and molecules to develop chemical probes and drug candidates and deliver compound for biological testing in timely manner Biochemistry: Protein overexpression and purification, recombinant DNA techniques and tools for constructing plasmids and vectors, protein structure determination (X-ray, NMR, cryoEM), protein-ligand interaction analysis by biophysical methods, and assay development Cell biology and pharmacology: Cellular assays, western blot, siRNA, proteomics, immunofluorescence, flow cytometry, and in vivo experiments to test small molecules and elucidate pharmacological mechanism of action Contact email: skita@scripps .edu Reference Number: EINSTEIN PD 56 Department Name: CELL BIOLOGY Postdoctoral or Instructor Position: Molecular Genetics of DNA Replication and Repair of the Mammalian Genome. An exciting Postdoctoral Fellow or Instructor position (Jr. Faculty Member) is available in the laboratory of Dr. Carl L. Schildkraut in the Department of Cell Biology and the Einstein Institute of Aging Research, Albert Einstein College of Medicine in New York. We broadly focus on studying the role of DNA replication and DNA damage in cancer, aging and neurological disease. Current projects include:. 1. The role of several genes, that have been implicated in Alzheimer's disease . 2. Identification of genes that contribute to exceptional longevity in humans. 3. The effect of DNA damage to genes involved in neurological disease. 4. The molecular mechanism of telomere replication. We are seeking a highly motivated individual with a strong interest in basic science research with translational potential. Applicants must be Ph.D. or MD/Ph.D. graduates in cell biology, molecular biology, cancer biology, molecular genetics, biophysics, developmental biology or related fields. Prior experience in DNA replication and repair is preferred. The position offers excellent opportunities for publications and career development and the opportunity to develop your own ideas. The laboratory has long-term NIH support. https://einsteinmed.edu/departments/cell-biology/faculty/carl-schildkraut/ The Cell Biology Department at Einstein provides an outstanding research environment with stimulating faculty with a strong interest in interacting with and supporting young scientists; https://einsteinmed.edu/departments/cell-biology/ Contact email: carl.schildkraut@einsteinmed.edu Reference Number: EINSTEIN PD 57 Department Name: NEUROLOGY Postdoctoral research positions are available in the Saul R. Korey Department of Neurology, Laboratory of Developmental Epilepsy of the Albert Einstein College of Medicine, in the laboratory of Dr Aristea Galanopoulou. This laboratory has special interest in epileptogenesis through the lifespan and developing better treatments for epilepsies and comorbidities. The position is for a research project on post-traumatic epilepsy and will involve use of rodent model of post-traumatic epilepsy, behavioral test, histology, electrophysiology methods, and other assays for protein or gene expression. The ongoing projects in the lab utilize various techniques including stereotactic surgeries, video-EEG recording and analysis, electrochemical assays, behavioral studies, histological evaluation, molecular biology, in vitro and in vivo electrophysiology studies. Special consideration will be given to applicants with prior experience in the above techniques and methods, a strong training background in epilepsy research or electrophysiology or neuroscience, and who are highly motivated to contribute to this research area. Prior research experience in any of the above areas is preferred. Contact email: aristea.galanopoulou@einsteinmed.edu Reference Number: EINSTEIN PD 58 Department Name: ONCOLOGY, MICROBIOLOGY/MMUNOLOGY AND PATHOLOGY The Saenger laboratory at the Albert Einstein College of Medicine is recruiting a post-doctoral fellow to work on NCI funded research in immune biomarkers for cancer. The laboratory currently includes an assistant research professor and three technicians as well as the PI and the work focuses on studying tumor specimens and developing organoid models to dissect underlying mechanisms of clinical observations. Our group has previously developed biomarkers for clinical application in melanoma and we are actively working on biomakerkers for liver cancer. We are looking to understand the phenotypes of cells we have identified using NGS and qmIF methods in organoid models. The post-doc will work with a multi-disciplinary team of computational biologists, clinicians and immunologists. There will also be extensive contact with industry. Dr. Saenger leads the Immune Monitoring Core as well as the Immunotherapy Program at Albert Einstein College of Medicine. The immune monitoring core has state of the art equipment for analysis of tumor specimens including a Vectra Polaris and the NanoString Digital Spatial Profiling platform. Familiarity with programming preferred. Enthusiasm essential. The candidate should be highly driven and excited about immunotherapy research. Career development and mentoring provided by the PI and opportunity for high level publications and strong support from the laboratory team as well as presentations at national and international conferences. Contact email: yvonne.saenger@einsteinmed.edu Reference Number: EINSTEIN PD 59 Department Name: SYSTEMS AND COMPUTATIONAL BIOLOGY The Chang Lab has an open postdoc position for interdisciplinary research integrating computation and bench experiments. Our research pursues biological mechanisms of toxicity and resistance to oxidative stress spanning multiple scales of complexity from molecules to whole cells, with special emphasis on the proteome. We focus on disease and treatment-oriented applications and also on model and commensal bacteria. Approaches include: 1) protein-structure-resolved, genome-scale metabolic network modeling and multi-omics measurements of stress phenotypes, 2) machine learning of modifications to protein structure caused by stress exposure, and 3) engineering proteins to alter how they are impacted by stress. This research has broad translational implications for medicine and general biotechnology. The ideal candidate has a PhD in computational biology, data science, bioinformatics, systems biology, or related subjects, has extensive analytical and coding experience, and working knowledge of protein structure. Although this is primarily a computational position, at least some wet lab experience in basic molecular biology, biochemistry, proteomics, microbiology, or mammalian cell culture is a plus. For more information, please visit: https://einsteinmed.edu/labs/roger-chang Contact email: roger.chang@einsteinmed.edu Reference Number: EINSTEIN PD 60 Department Name : NEUROLOGY We are seeking to fill a post-doctoral fellow position to work on NIH funded studies in the Division of Cognitive & Motor Aging in the Saul R. Korey Department of Neurology at the Albert Einstein College of Medicine. The post-doctoral fellow will work with a multidisciplinary team to examine Motoric Cognitive Risk syndrome (MCR), a pre-dementia syndrome associated with increased risk of developing Alzheimer's disease and related dementias. The fellow will be responsible for analyzing and harmonizing biological and clinical data across our multi-country sites. The fellow will be involved in tracking progress, and communicating with the investigators and coordinators at study sites.The fellow will work with a multidisciplinary team of investigators, and have the opportunity to develop their own independent research projects, make scientific presentations, and publish manuscripts. Strong mentoring, training support and career development will be provided by an internationally recognized team of researchers. Contact email: Emmeline.Ayers@einsteinmed.org Reference Number: EINSTEIN PD 61 Department Name: MEDICINE AND MICROBIOLOGY AND IMMUNOLOGY A position is open for the study of protective antibody responses and functions against M. tuberculosis. This will be especially of interest for applicants who want to expand or gain experience in translational research. Specific interests of the laboratory include understanding the role of the human humoral immune response to M. tuberculosis in patients at various states of infection. These include i) large scale tuberculosis serology studies using innovative techniques to identify both antibodies that can serve as tuberculosis biomarker as well as those with protective functions, ii) isolation and generation of monoclonal human antibodies to M. tuberculosis antigens, and iii) detailed studies of antibody mechanism against M. tuberculosis in vitro and in vivo . Candidates should have a strong background in Immunology and/or Microbiology. Contact email: jacqueline.achkar@einsteinmed.edu Reference Number: EINSTEIN PD 62 Department Name: GENETICS The Raj lab is interested in using population genetics and computational approaches to understand the contribution of population structure to variation in common and rare disease risk, etiology and outcome in different populations, particularly those in the Bronx. Two postdoctoral positions are available A: A population geneticist interested in studying population genetic variation using biobank-scale data, with a particular focus on cancer or common chronic disease. B: A geneticist interested in combining wet and dry lab techniques to study the functional consequences of population genetic variation. Contact email: srilakshmi.raj@einsteinmed.edu Reference Number: EINSTEIN PD 63 QUALIFICATIONS All candidates must have a MD or Ph.D. Degree Excellent references

Bronx, New York

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