GENERAL SUMMARY/OVERVIEW STATEMENT: A full-time research technician position is immediately available in the laboratories of Dr. Ryan Corcoran and Dr. Nicholas Dyson at Massachusetts General Hospital Cancer Center. The Corcoran lab is involved in investigating new and effective therapies for gastrointestinal cancers, mainly colorectal, pancreatic and liver cancers. Our group is interested in elucidating novel mechanisms of resistance to targeted cancer therapeutics such as kinase inhibitors or immune checkpoint inhibitors (Hazar-Rethinam M et al. Cancer Discovery 2018 , Ryan MB et al. Clinical Cancer Research 2019 , Tanaka N et al. Cancer Discovery 2021 ). The Dyson lab is involved in understanding the molecular mechanism of acquired chemoresistance in Small Cell Lung Cancer (SCLC) and investigating new and effective therapies for this malignancy. We are using both established SCLC cell lines and a panel of patient derived xenograft models that we build by isolating tumor cells from SCLC patients. Examples of our scientific focus can be find in these publications: Drapkin et al. Cancer Discovery 2018 , Farago et al. Cancer discovery 2019 . We seek a highly motivated individual with a strong interest in pursuing a future academic career in science or medicine. This is an ideal position for a recent graduate who wants to gain an intense research experience before pursuing graduate school. The candidate will take responsibility in basic science and translational research projects under close supervision of post-doctoral research fellows in the lab, as well as Dr. Ryan Corcoran (PI) and Dr. Nicholas Dyson (PI). Our current technicians have varied roles within the lab. You will be introduced and trained on the following techniques, depending on the departmental need. We encourage you to apply, regardless of prior experience in these specific laboratory techniques below. Duties and Responsibilities: In vivo assessment of drug response in mouse models, establishment of tumor xenografts, drug treatment and harvesting of tumor tissue. Tissue culture techniques: maintenance of mouse/human cell lines in culture, cryopreservation, drug treatments, plasmid transfections, lentiviral transduction. Perform standard molecular biology techniques (Western blotting, PCR, cloning, site-directed mutagenesis, CRISPR). Generation and maintenance of organoid cultures from patient biopsies. Interpretation of experimental results. Interest on establishing new and optimizing existing techniques in the lab. SKILLS/ABILITIES/COMPETENCIES REQUIRED : Ability to work independently and as a team member Good communication skills Computer literacy Working knowledge of clinical research protocols Ability to perform multiple tasks independently Qualifications EDUCATION: Bachelor's degree in a biological science required. EXPERIENCE: Prior research experience in a molecular biology laboratory is preferred (internships, rotations, undergrad lab experience, etc.) Knowledge of Microsoft Office. Self-motivated, excited about conducting research in cancer biology. The candidate must be reliable, meticulous in record keeping, and able to work independently, as well as with a team. Excellent organizational and analytical skills. EEO Statement Massachusetts General Hospital is an Equal Opportunity Employer. By embracing diverse skills, perspectives and ideas, we choose to lead. Applications from protected veterans and individuals with disabilities are strongly encouraged.Partner's Healthcare is acting as an Employment Agency in relation to this vacancy.