Cambridge, Massachusetts

We are looking for skilled and ambitious individuals excited to unlock next-generation gene therapy-based cures for previously incurable genetic disorders. Description: Our laboratory at Harvard Medical School is starting a new project whose mission is to pioneer the next generation of gene therapy vectors with programmable specificity and transgene expression. We employ PESCA1, a single-cell screening platform developed in-house, to sift through the mammalian genome and identify regulatory elements capable of driving optimal patterns of transgene expression to address a wide range of diseases. In collaboration with industry partners, we develop new extensions of the PESCA platform to advance our ability to create gene therapy vectors with precisely controlled expression in any desired cell type. We are recruiting a full-time Research Scientist to join our team, whose primary responsibility will be to collaboratively develop and drive multiple iterations of the PESCA pipeline simultaneously. Day-to-day responsibilities include supervising and managing 1-2 research assistants, as well as interpreting and troubleshooting experimental results, to ensure continued progress on all projects. The work involves application of cutting-edge single-cell genomic technologies and interested applicants should be sufficiently experienced in wet lab work such that they can capably perform all steps of the PESCA pipeline. The position requires coordination of existing industry partnerships and multitasking to keep simultaneously ongoing projects on track. We are seeking highly motivated individuals with strong scientific backgrounds capable of efficient experimental planning, delegation, and management, who are excited by the prospect of pushing multiple projects to completion in a fast-paced academic setting. The position will report directly to our core group of scientific leadership, offering a unique opportunity to play a lead role in developing promising new viral vectors of high therapeutic potential as part of a highly collaborative and dynamic research group. https://elifesciences.org/articles/48089 Responsibilities: Collaboratively develop and strategically drive multiple implementations of the PESCA platform under supervision of core scientific leadership Supervise, advise, and train research assistants who will perform bench experiments Prepare daily experimental schedules and delegate tasks across team Troubleshoot experiments or results and advise next steps Use formal scheduling tools to ensure team coordination Prioritize experiments with dynamic and flexible thinking and continuous evaluation of experimental quality and rigor Coordinate with industry partners Compose written project update summaries and present update slide decks Report to core PESCA team leadership Share insights for platform improvement and optimization This is a 12-month term appointment with the possibility of renewal contingent on funding. Offer contingent upon successful completion of a pre-placement medical evaluation. This is an in-person position based on our campus in Boston. The University requires all Harvard community members to be fully vaccinated against COVID-19 and remain up to date with COVID-19 vaccine boosters, as detailed in Harvard's Vaccine & Booster Requirements . Individuals may claim exemption from the vaccine requirement for medical or religious reasons. More information regarding the University's COVID vaccination requirement, exemptions, and verification of vaccination status may be found at the University's PhD in biological sciences, molecular biology, genomics, neuroscience, or related discipline 4+ years hands-on wet lab experience Interested individuals should be capable of performing all steps of the PESCA pipeline, including: Next-generation sequencing library preparation and analysis (bulk and single-cell ATAC-seq and RNA-seq) Molecular biology techniques, including qPCR, RT-qPCR, molecular cloning, immunofluorescence, and RNA in situ hybridization. FACS Cell culture AAV purification and delivery Mouse handling and colony maintenance Strong organizational and documentation skills Good time management and rigorous scheduling, as multiple projects must progress simultaneously Good interpersonal and collaborative skills to maintain a friendly and professional working environment Strong scientific communication skills to keep project supervisors informed and present data to academic and industry collaborators Experience managing multiple high-budget projects in industry or academic setting EQUAL OPPORTUNITY EMPLOYER: We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, or any other characteristic protected by law.

Cambridge, Massachusetts

The Higher Education Recruitment Consortium (HERC) is a national nonprofit network of higher education and affiliated employers, committed to institutional collaboration, creating diverse workplaces, and assisting dual career couples. Searching for a job in higher ed? Our job board hosts over 30,000 faculty and staff jobs at workplaces that value diversity, equity, and inclusion. Set up your job seeker account today at: http://www.hercjobs.org For our member institutions, we offer recruitment and retention resources, vibrant regional networks, and a new online community of practice, HERConnect. All of our resources can help you advance inclusive excellence at your institution.

Similar jobs