Madison, Wisconsin

Job Summary: The Department of Medicine is looking for a Scientist to work in the Center for Human Genomics and Precision Medicine. This position will work to develop ex vivo tools for the prediction of targeted therapeutic response and overcome secondary mechanisms of resistance in gastrointestinal malignancies. Patient-derived cancer organoids (PCOs) provide a platform to understand the mechanism of therapeutic selection. These technologies interface with broad advances in next-generation sequencing, broad expression profiling, high-throughput screening, advanced microscopy, and animal models. By focusing efforts from patient-derived tissues these projects have potential to translate to effective therapies in early the phase clinical trials. The lab scientist will have direct responsibility of the day-to-day aspects of sample preparation, processing, high-throughput drug screening, investigating the spectrum of anticancer activity of experimental agents and identify molecular mechanisms of action. These will be achieved using a breadth of modalities including molecular profiling, blot analysis, microarrays, and high content imaging. SMPH is committed to being a diverse, equitable, inclusive and anti-racist workplace and is an Equal Employment Opportunity, Affirmative Action employer. Applications from Black, Indigenous and People of Color (BIPOC) individuals, LGBTQ+ and non-binary identities, women, persons with disabilities, military service members and veterans are strongly encouraged. Responsibilities: Scientist II (RE044) Scientist III (RE045) Institutional Statement on Diversity: Diversity is a source of strength, creativity, and innovation for UW-Madison. We value the contributions of each person and respect the profound ways their identity, culture, background, experience, status, abilities, and opinion enrich the university community. We commit ourselves to the pursuit of excellence in teaching, research, outreach, and diversity as inextricably linked goals. The University of Wisconsin-Madison fulfills its public mission by creating a welcoming and inclusive community for people from every background - people who as students, faculty, and staff serve Wisconsin and the world. For more information on diversity and inclusion on campus, please visit: Diversity and Inclusion Education: Required Terminal Degree Ph.D. in Drug discovery, Pharmacology, Molecular Biology, Biochemistry, Cancer Biology, Pharmacy or related field required. Qualifications: Required: -Minimum 2-3 year of post-doctoral experience in cancer drug discovery and drug development, pharmacology -Strong hands-on experience with organoid culture, advanced imaging, molecular and cellular techniques, drug discovery, pharmacology and in vivo/ex vivo experimental models - Excellent analytical and writing skills - Demonstrated ability to work collaboratively with university faculty and clinicians, providing leadership on a major component of a project -A history of professional publication/dissemination of findings -Strong track record in cancer drug discovery/translational research and the development of small-molecule inhibitors -Extensive experience in cancer research, tumor microenvironment biology or related fields, and a desire to continue in a laboratory-focused role -Specific expertise in the study of cell cycle related pathways - Experience with program or project evaluation. Experience conceptualizing projects, designing experiments and writing manuscripts and grants Preferred: Established publication record -Experience performing patient derived organoid (3D), patient-derived xenograft (PDX), molecular biology and flow cytometry techniques preferred. These include cell culture, cloning, nucleic acid isolation, cell surface staining, multi-parameter flow cytometry, and drug discovery and development -Experience with sample preparation, processing, and antibody labeling -Gene editing and transfection experience -3D organoids and stem cell culture experience -Primary cell culture experience -Experiences in fully synthetic matrix biology -UW-Madison experience COVID-19 Considerations: UW-Madison continues to follow necessary health and safety protocols to protect our campus from COVID-19. All employees remain subject to the COVID-19 Workplace Safety Policy: https://policy.wisc.edu/library/UW-5086 . Please visit https://covidresponse.wisc.edu for the most up-to-date information. Work Type: Full Time: 100% It is anticipated this position requires work be performed in-person, onsite, at a designated campus work location. Appointment Type, Duration: Ongoing/Renewable Salary: Negotiable ANNUAL (12 months) Additional Information: Hire will be subject to criminal background check requirements. A period of evaluation will be required. How to Apply: To apply for this position, please click on the "Apply Now" button. You will be asked to upload a resume, cover letter, and list of three professional/supervisor references as a part of the application process. References will not be contacted without prior notice. Please ensure that the resume and cover letter address how you meet the minimum/preferred qualifications for the position. Contact: Charles Amble caamble@medicine.wisc.edu 608-265-9049 Relay Access (WTRS): 7-1-1 (out-of-state: TTY: 800.947.3529, STS: 800.833.7637) and above Phone number (See RELAY_SERVICE for further information. ) Official Title: Scientist II(RE044) or Scientist III(RE045) Department(s): A534260-MEDICAL SCHOOL/MEDICINE/HEM-ONC Employment Class: Academic Staff-Renewable Job Number: 259336-AS   The University of Wisconsin is an Equal Opportunity and Affirmative Action Employer. We promote excellence through diversity and encourage all qualified individuals to apply. If you need to request an accommodation because of a disability, you can find information about how to make a request at the following website: https://employeedisabilities.wisc.edu/disability-accommodation-information-for-applicants/ Employment will require a criminal background check. It will also require you and your references to answer questions regarding sexual violence and sexual harassment. The University of Wisconsin System will not reveal the identities of applicants who request confidentiality in writing, except that the identity of the successful candidate will be released. See Wis. Stat. sec. 19.36(7). The Annual Security and Fire Safety Report contains current campus safety and disciplinary policies, crime statistics for the previous 3 calendar years, and on-campus student housing fire safety policies and fire statistics for the previous 3 calendar years. UW-Madison will provide a paper copy upon request; please contact the University of Wisconsin Police Department .

Madison, Wisconsin

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