Durham, North Carolina

This Position is Fully Grant Funded

School of Medicine Established in 1930, Duke University School of Medicine is the youngest of the nation’s top medical schools. Ranked sixth among medical schools in the nation, the School takes pride in being an inclusive community of outstanding learners, investigators, clinicians, and staff where interdisciplinary collaboration is embraced and great ideas accelerate translation of fundamental scientific discoveries to improve human health locally and around the globe. Composed of more than 2,500 faculty physicians and researchers, more than 1,300 students, and more than 6,000 staff, the Duke University School of Medicine along with the Duke University School of Nursing, Duke University Health System and the Private Diagnostic Clinic (PDC) comprise Duke Health. a world-class academic medical center. The Health System encompasses Duke University Hospital, Duke Regional Hospital, Duke Raleigh Hospital, Duke Primary Care, Duke Home and Hospice, Duke Health and Wellness, and multiple affiliations.

 

 

 

 

 

Postdoctoral Associate Position

(Acharya Lab, Division of Structural Biology)

 

The Acharya Lab in the Division of Structural Biology at the Duke Human Vaccine Institute (DHVI) is recruiting for a Postdoctoral Associate. DHVI is an interdisciplinary, interdepartmental institute dedicated to the study of basic and translational science required to understand host-pathogen interactions that can be translated to vaccines against human diseases. We are a team of highly interactive investigators that have expertise in immunology, molecular biology, virology, microbiology, structural biology, computational biology, and vaccine science.

 

The Acharya Lab applies structural biology to study viral glycoproteins, their interactions with host receptors and role in viral entry. Working at the interface of basic and translational research, we collaborate with multiple labs in DHVI and beyond to apply insights from structural biology to vaccine design. We have state-of-the-art facilities that include tissue culture and protein purification infrastructure, robots for X-ray crystallography, Biacore T200 and Octet Red 384 for measurement of intermolecular interactions, and a Leica EM GP2 for cryo-EM grid preparation. We have regular access to the 22-ID beamline at the Argonne Photon Source for X-ray data collection, and to a Titan Krios microscope at Duke University for cryo-EM.

 

This position will involve projects that will use high-resolution cryo-EM and X-ray crystallography to determine structures of viral surface proteins in complex with host receptors and antibodies. Combining structural findings with biophysical and biochemical analyses, and complementing these with collaborations with virology and immunology labs, we will explore the mechanism of viral entry and translate the knowledge gained for vaccine and therapeutics design.

 

At DHVI our postdoctoral associates work in concert with Duke faculty and staff in an invigorating research training environment. One of our primary scientific missions is to support and train early stage investigators to be the next generation of scientific leaders equipped to identify and implement solutions for improving human health worldwide. DHVI functions as a vaccine development biotechnology enterprise, embedded within a top university. As a trainee within our mentoring program, you will interact with highly innovative and collaborative investigators and will have the opportunity to master state of the art technologies. We are committed to providing an outstanding training environment and research experiences that will enhance your career and provide you an avenue to incorporate your education, expertise, initiative and dedication to the success of the studies we will undertake. This is an opportunity to become part of a winning team that is working to discover novel ways to prevent infectious diseases.

 

The successful candidate will have a Ph.D. degree, with a strong background in biochemistry and structural biology. Experience in protein expression, purification, and either X-ray crystallography or cryo-EM is required. The candidate will be creative, motivated, and able to work independently, as well as part of a team.

 

 

Please contact priyamvada.acharya@duke.edu for more information.

 

Duke is an Affirmative Action/Equal Opportunity Employer committed to providing employment opportunity without regard to an individual's age, color, disability, gender, gender expression, gender identity, genetic information, national origin, race, religion, sex, sexual orientation, or veteran status.

 

Duke aspires to create a community built on collaboration, innovation, creativity, and belonging. Our collective success depends on the robust exchange of ideas—an exchange that is best when the rich diversity of our perspectives, backgrounds, and experiences flourishes. To achieve this exchange, it is essential that all members of the community feel secure and welcome, that the contributions of all individuals are respected, and that all voices are heard. All members of our community have a responsibility to uphold these values.

 

Essential Physical Job Functions: Certain jobs at Duke University and Duke University Health System may include essentialjob functions that require specific physical and/or mental abilities. Additional information and provision for requests for reasonable accommodation will be provided by each hiring department.

 

Durham, North Carolina

As a world-class academic and health care system, Duke Health strives to transform medicine and health locally and globally through innovative scientific research, rapid translation of breakthrough discoveries, educating future clinical and scientific leaders, advocating and practicing evidence-based medicine to improve community health, and leading efforts to eliminate health inequalities.

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