Silver Spring, Maryland

Responsibilities for this Position
Location: USA MD Silver Spring - 503 Robert Grant Ave (MDC225)
Full Part/Time: Full time
Job Req: RQ114109

Type of Requisition:
Regular

Clearance Level Must Currently Possess:
None

Clearance Level Must Be Able to Obtain:
None

Public Trust/Other Required:
NACI (T1)

Job Family:
Scientists

Job Description:

The Walter Reed Army Institute of Research (WRAIR) aims to conduct biomedical research that is responsive to Department of Defense (DOD) and US Army requirements and delivers life-saving products including knowledge, technology and medical material that sustain the combat effectiveness of the Warfighter. Our team is seeking technical expertise to provide support to WRAIR's Center for Military Psychiatry and Neuroscience Research (CMPN) CMPN is a translational and expeditionary effortto identify and eliminate brain health threats to Soldiers. CMPN investigates and manipulates the relationship between sleep and performance, performs behavioral health assessments to inform unit Commanders on Soldier behavioral health needs, and develops and implements resilience trainings. On a parallel track are efforts to identify and treat traumatic brain injury as well as understand the impactof repeated blast exposure.

Specifically, our team is seeking a Principal Investigator to support the Blast Induced Neurotrauma Branch within CMPN. The Blast Induced Neurotrauma (BINT) Branch uses models to validate and characterize scaled experimental blast exposure conditions and assess outcomes relevant to blast-injured Warfighters to define the biomechanical and neurobiological underpinnings of blast TBI and establish effective countermeasures. BINT's mission in the field: is to characterize individual operator blast exposures in a variety of training environments to identify the effects of blast overpressure exposures on cognitive performance, brain and blood biomarkers, and symptom reporting.

Responsibilities:
  • Provide technical expertise to conduct and analyze brain trauma neuroprotection, neurorestoration, and neurotherapeutic research , including therapeutic strategies, blood-brain barrier (BBB) permeability, immune-inflammatory responses, biomarkers, pathology and sequalae following trauma as well as the molecular and cellular mechanisms of brain injury.
  • Implement the execution of research tests on the behavioral, physiological, electrophysiological (including seizures and sleep) and cellular/molecular pathology of brain and spinal cord trauma. These tests shall include, but are not limited to, Morris water maze, rotarod, novel object recognition, elevated plus maze, monitoring weight, temperature, Neuroscore, righting reflex, EEG recording of seizure and sleep, positron emission tomography analysis, Ultrasonic Vocalization, perfusion, resuscitation, proteomics, necropsy and sample collection procedures, mRNA, miRNA, micro array protein analysis, quantitative PCR, Western blot, or ELISA.
  • Perform and oversee aspects of field study preparation to include calibration of equipment, ensuring that adequate supplies are on hand for data collection (e.g., blast sensing systems, neurocognitive performance assessment batteries, physiological monitoring devices, etc.), and perform documentation associated with the field study.
  • Lead a multidisciplinary team of doctoral level scientific researchers, to include physicians, psychologists, physiologists and statisticians and critically analyze and review multidisciplinary research proposals and publications for military relevance and scientific adequacy.
  • Provide support to monitoring research animals, conduct research experiments to meet the goals of the tasks, process research data files, and analyze research data.
  • Plan and execute research experiments related to polytrauma injury, accounting for the impact of hemorrhagic shock on the progression brain injury using resuscitation approaches that optimize cerebral perfusion and brain salvage, immune-inflammatory responses, and other related physiological changes.
  • Examine therapeutic approaches by isobolic design and analysis framework using well-established and promising novel neuro-protective agents, stem-cell based therapies, and novel drug delivery systems.
  • Plan and execute research experiments focusing on mitochondrial therapeutic interventions, including allogeneic mitochondrial transplantation, pharmacological approaches, and enhancing mitochondrial bioenergetics.
  • Plan and execute research experiments evaluating the neuroprotective benefits of neuroprotective and cognition-enhancing therapeutic drugs (NPCED) treatment, including profiles of pro-inflammatory, apoptotic, and neurotrophic factors, as well as specialized histopathology and immunohistochemistry analysis.

Qualifications:
  • Requires a doctorate degree and post-doctoral training in physiology and/or neuroscience with extensive hands-on experience in rodent surgery and physiological monitoring techniques related to bTBI as well as a minimum of 8 years of experience.
  • Demonstrates expertise in a variety of the field's concepts, practices, and procedures.

Scheduled Weekly Hours:
40

Travel Required:
None

Telecommuting Options:
Hybrid

Work Location:
USA MD Silver Spring

Additional Work Locations:

COVID-19 Vaccination: GDIT does not have a vaccination mandate applicable to all employees. To protect the health and safety of its employees and to comply with customer requirements, however, GDIT may require employees in certain positions to be fully vaccinated against COVID-19. Vaccination requirements will depend on the status of the federal contractor mandate and customer site requirements.

We are GDIT. The people supporting some of the most complex government, defense, and intelligence projects across the country. We deliver. Bringing the expertise needed to understand and advance critical missions. We transform. Shifting the ways clients invest in, integrate, and innovate technology solutions. We ensure today is safe and tomorrow is smarter. We are there. On the ground, beside our clients, in the lab, and everywhere in between. Offering the technology transformations, strategy, and mission services needed to get the job done.

GDIT is an Equal Opportunity/Affirmative Action employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or veteran status, or any other protected class.

PI177531212

Silver Spring, Maryland

General Dynamics is a global aerospace and defense company.

Our portfolio spans the realm of the world's most technologically advanced business jets, wheeled combat vehicles, command and control systems and nuclear submarines. We offer these through our five business groups: Aerospace, Combat Systems, Information Technology, Mission Systems and Marine Systems.

General Dynamics employs thousands of people across the globe, with locations in more than 45 countries. We rely on the skills of our employees and their knowledge of customer requirements to deliver best-in-class products and services.

Who We Are Looking For 

General Dynamics is seeking military veterans and military spouses across the country who bring a deeply rooted skillset that includes team-oriented approaches to problem-solving, demonstrations of leadership and an overall commitment to the mission of the organization.  We recognize the knowledge and skills gained during your military experience are invaluable to the success of a team. We’re proud of the thousands of veterans and military professionals who have chosen to apply their leadership, teamwork and problem-solving skills to a career at General Dynamics and to continue supporting the mission of those serving today.

Should I Apply?

At General Dynamics, our employees are the heart of our company. We rely on their dedication to excellence and their intimate knowledge of customer requirements to meet the needs of customers around the globe, day in and day out. Our employees' unique blend of skill, innovation and agility drives our continued success, and we take our responsibility to them seriously. If you are a military veteran or military spouse ready to advance your career, view our available career opportunities to the right for more information and to apply today!

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