Boston, Massachusetts

Job Description

New hires based in the US & Puerto Rico will be required to demonstrate that they have been fully vaccinated for COVID-19 or qualify for a medical or religious exemption or accommodation to this vaccination requirement, subject to applicable law.

This position is within the Computational and Structural Chemistry group department at our company's Research Laboratories in Boston, MA, USA. This group supports drug discovery using atomic resolution single particle cryo-EM and x-ray diffraction to determine the structure of therapeutically important targets. The successful candidate will be responsible for all aspects of the structural biology process, from sample preparation and data collection through data processing and structure determination, and will work closely with molecular biologists, biochemists and biophysicists who employ state-of-the art capabilities to drive drug design. We are an integral arm of both discovery and process chemistry and collaborate seamlessly with teams around the globe to innovate and invent better molecules faster.

Productive and collaborative interactions with other members of the global, cross-functional department are required. There is an expectation for periodic travel to other locations. Cooperative and collaborative use of internal expertise and resources will be essential to success. The position requires active interaction with the external scientific community to continually improve scientific understanding, including presentations at national or international meetings.

Consistently cited as a great place to work, our company employs talented people who discover, develop, manufacture, and market a wide range of vaccines and medicines to address unmet medical needs. Each of us is joined by an extraordinary sense of purpose — bringing our company's finest achievements to people worldwide. The company's Boston campus is located within the heart of industry in the greater Boston and Cambridge areas allowing for close interactions with the quickly-expanding high resolution single particle cryo-EM community as well as the structural biology field at large, giving easy access to the latest developments in the field.

Required Experience and Skills:

  • PhD degree in structural biology field.

  • Demonstrated experience in a broad range of activities for x-ray crystallography and/or atomic resolution single particle cryo-EM, including sample preparation, data collection, image processing & structure determination.

  • Excellent communication skills (written, presentation, and oral) that enhance team-based progress is required.

  • Application of those skills both within and outside the department to ensure the maximum understanding of program status for therapeutic area project teams and management is required.

  • Demonstrated potential to develop project management skills and identify/develop new areas of scientific expertise in structural biology.

  • Expectation to support an inclusive workplace through positive actions, and a demonstration of both receiving and giving honest professional feedback.

  • Ability to work effectively and flexibly within timelines.

  • Demonstrated ability to prepare peer-reviewed publications

Preferred Experience and Skills:

  • PhD degree with at least two years of postdoctoral training in structural biology field

  • Experience with biophysical and functional characterization methods (e.g. SPR, NMR, thermal shift and calorimetric assays) to guide construct design and optimization of solution conditions for successful structural outcomes

  • Experience with structure determination of small molecule : protein complexes

  • Experience with structure determination of peptide protein : complexes.

  • Experience with the application of hybrid structural techniques to answer biological questions

  • Ability to manage multiple projects and subsequent prioritization

  • Experience using computational tools for protein engineering and design.

We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we “follow the science” that great medicines can make a significant impact to our world. We believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe.

Who we are …

We are known as Merck & Co., Inc., Kenilworth, New Jersey, USA in the United States and Canada and MSD everywhere else. For more than a century, we have been inventing for life, bringing forward medicines and vaccines for many of the world's most challenging diseases. Today, our company continues to be at the forefront of research to deliver innovative health solutions and advance the prevention and treatment of diseases that threaten people and animals around the world.

What we look for …

In a world of rapid innovation, we seek brave Inventors who want to make an Impact in all aspects of our business, enabling breakthroughs that will affect generations to come. We encourage you to bring your disruptive thinking, collaborative spirit and diverse perspective to our organization.

NOTICE FOR INTERNAL APPLICANTS

In accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.

If you have been offered a separation benefits package, but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separation package, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor.

Residents of Colorado

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US and Puerto Rico Residents Only:

Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process.

For more information about personal rights under Equal Employment Opportunity, visit:

EEOC Poster

EEOC GINA Supplement

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Pay Transparency Nondiscrimination

We are proud to be a company that embraces the value of bringing diverse, talented, and committed people together. The fastest way to breakthrough innovation is when diverse ideas come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively. We are an equal opportunity employer, committed to fostering an inclusive and diverse workplace.

Search Firm Representatives Please Read Carefully
Merck & Co., Inc., Kenilworth, NJ, USA, also known as Merck Sharp & Dohme Corp., Kenilworth, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

Employee Status:

Regular

Relocation:

Domestic/International

VISA Sponsorship:

Yes

Travel Requirements:

10%

Flexible Work Arrangements:

Shift:

Valid Driving License:

Hazardous Material(s):

Number of Openings:

1

Requisition ID:R154579

Boston, Massachusetts

Today's Merck is a global healthcare leader working to help the world be well. Merck is known as MSD outside the United States and Canada. Through our prescription medicines, vaccines, biologic therapies, and consumer care and animal health products, we work with customers and operate in more than 140 countries to deliver innovative health solutions. We also demonstrate our commitment to increasing access to healthcare through far-reaching policies, programs and partnerships. For more information, visit www.merck.com.

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