Durham, North Carolina

School of Medicine:


Established in 1930, Duke University School of Medicine is the youngest of the nation’s top medical schools. Ranked tenth among its peers, the School takes pride in being an inclusive community of outstanding learners, investigators, clinicians, and staff where traditional barriers are low, interdisciplinary collaboration is embraced, and great ideas accelerate translation of fundamental scientific discoveries to improve humanhealth locally and around the globe.


Comprised of 2,400 faculty physicians and researchers, the Duke University School of Medicine along with the Duke University School of Nursing and Duke University Health System create Duke Health. Duke Health is a world-class health care network. Founded in 1998 to provide efficient, responsive care, the health system offers a full network of health services and encompasses Duke University Hospital, Duke Regional Hospital, Duke Raleigh Hospital, Duke Primary Care, Private Diagnostic Clinic, Duke Home and Hospice, Duke Health and Wellness, and multiple affiliations.


Lab Research Analyst II (LRA II)

Position Description:

Occupational Summary:

The Duke University School of Medicine is seeking a Laboratory Research Analyst II for the Duke Proteomics and Metabolomics Core Facility (https://genome.duke.edu/cores-and-services/proteomics-and-metabolomics). The Core Facility is currently staffed with ten scientists (five PhDs, four of whom are Research Professors in the School of Medicine) with a combined 160+ years’ experience in the analysis of peptides, proteins, and small molecules. The Facility is equipped with ~$10M in dedicated LC-MS/MS hardware and software, and it is located in a custom-built (2017) 8,100 sq. ft. laboratory.  Seeking a self-starting scientist with good problem-solving skills and strengths in quantitative analysis, particularly by LC-MS/MS.  Job duties will be to work in a fast-paced, team-based environment to conduct a variety of complex and independent investigations addressing physical, chemical, and other research laboratory experiments to obtain and interpret data for research projects at Duke, specifically addressing metabolomics and proteomics in cancer, neurodegenerative diseases, and infectious diseases.  Scientific integrity, curiosity, and determination are key qualities of a successful candidate.

In particular, the Lab Research Analyst II will conduct a variety of complex laboratory procedures and specialized laboratory techniques for the analysis of endogenous metabolites, drug molecules, peptides and proteins in the Proteomics and Metabolomics Core Facility for the School of Medicine.  Note that both SOP-driven and independent analyses will be required, and proven analytical thinking and problem-solving skills are critical.  The ability to effectively work in a multidisciplinary team environment and move easily from one task to another is essential.

Tasks may include:

1) 40% - Preparation of biological samples for metabolomic, proteomic, and pharmacokinetic analyses.

2) 30% - Quantification of metabolites using triple quadrupole mass spectrometry, and contribution to the development of new LC-MS/MS assays.  Validation of figures of merit for quantitative LC-MS/MS assay.


3) 10% - Protein identification and quantitation using nanoscale capillary liquid chromatography and analytical scale liquid chromatography coupled with either high resolution, accurate mass tandem mass spectrometers (LC/MS/MS) or triple quadrupole mass spectrometers operated in MRM mode.

4) 15% - Contribution to written reports and publications of results in collaboration with investigators inside and outside of Duke.  Review journals, abstracts, and scientific literature to keep abreast of new developments and to obtain information regarding previous experiments to aid in the design and development of original procedures and techniques.

5) 5% - Presentation of their ongoing work at group meetings and national meetings, and critical evaluation of new approaches for metabolomics and proteomics presented in the literature or by others.



Work requires a bachelor's degree in chemistry, biochemistry, biology or other directly related scientific field, plus four years’ experience.  A related master's degree or PhD may offset required years of experience on a 1:1 basis, e.g., a two-year master's degree in lieu of two years of experience.


Experimental design/planning, sample preparation, LC-MS/MS sample analysis and results interpretation skills are essential.  Additional skills in statistics, bioinformatics, or programming are a plus.


Duke is an Affirmative Action/Equal Opportunity Employer committed to providing employment opportunity without regard to an individual's age, color, disability, gender, gender expression, gender identity, genetic information, national origin, race, religion, sex, sexual orientation, or veteran status.


Duke aspires to create a community built on collaboration, innovation, creativity, and belonging. Our collective success depends on the robust exchange of ideas—an exchange that is best when the rich diversity of our perspectives, backgrounds, and experiences flourishes. To achieve this exchange, it is essential that all members of the community feel secure and welcome, that the contributions of all individuals are respected, and that all voices are heard. All members of our community have a responsibility to uphold these values.


Essential Physical Job Functions: Certain jobs at Duke University and Duke University Health System may include essentialjob functions that require specific physical and/or mental abilities. Additional information and provision for requests for reasonable accommodation will be provided by each hiring department.


Durham, North Carolina

As a world-class academic and health care system, Duke Health strives to transform medicine and health locally and globally through innovative scientific research, rapid translation of breakthrough discoveries, educating future clinical and scientific leaders, advocating and practicing evidence-based medicine to improve community health, and leading efforts to eliminate health inequalities.

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