West Point, Pennsylvania

Job Description

We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we “follow the science” that great medicines can make a significant impact to our world. We believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe. 

The Discovery Bioanalytics team within Pharmacokinetics, Pharmacodynamics and Drug Metabolism (PPDM) Department in West Point, Pennsylvania has an opening for a talented scientist in the field of biological mass spectrometry with an emphasis on LC/MS quantification of proteins. The incumbent will join a dynamic and well-equipped bioanalytical group supporting the early stage of drug discovery. This role will be primarily responsible for developing LC/MS based methods and strategies and performing quantitative analysis of therapeutic and endogenous proteins and peptides to support pharmacokinetics and pharmacodynamic studies. The ideal candidate should be a self-driven and creative thinker that wants to develop and implement innovative bioanalytical approaches using the latest technology in support of our Company's pipeline dedicated to developing novel therapeutic agents.   


Responsibilities:
•    Independently design and execute quantitative methods for biological drug candidates and candidate biomarkers using LC-MS based platforms including triple quadrupole (QQQ) and high resolution (HRMS) mass spectrometers, specifically: 
•    Develop sample preparation methods ranging from protein precipitation (PP) and solid phase extraction (SPE) to immunoaffinity enrichment with automated platforms such as Bravo AssayMAP and Hamilton liquid handlers.
•    Achieve desired assay performance and throughput with appropriate LC-MS platforms; optimize parameters on various triple-quadrupole and high-resolution mass spectrometers coupled with either normal flow or micro/nano-flow chromatography.
•    Analyze data and interpret results with a variety of software such as Analyst, MassLynx, Xcalibur, MassHunter, Watson, and Skyline.
•    Represent the Bioanalytics function in collaborations with cross-functional teams; deliver high quality quantitative or qualitative data to project teams for PK and PK/PD analysis.
•    Effectively document, track and communicate scientific findings and recommendations within cross-functional teams.
•    Help with maintaining bioanalytical lab operations


Education Requirement:
Ph.D. in Chemistry, Biochemistry, Pharmaceutical Sciences or related discipline with 0-2 years relevant experience 
OR master’s degree with a minimum of 4 years 
OR bachelor’s degree with a minimum of 7 years of relevant experience

Required Experience and Skill Set:
•    Experience in quantification of proteins and peptides (i.e. xenobiotics, biomarkers) in biological samples with LC-MS/MS.
•    Advanced knowledge in biochemical techniques for sample preparation and enrichment of targeted protein analytes; hands-on experience in instrumentation, trouble shooting, QC, standardization for targeted proteomics workflow.
•    A keen interest in the latest developments in the field of protein mass spectrometry, willingness to develop innovative bioanalytical approaches to solve historically challenging problems in bioanalysis.  
•    Strong interpersonal, communication, collaboration, and problem-solving skills.
•    Excellent verbal and written communication skills; ability to excel in a team-based environment.
•    Proven record of innovation with publications in peer-reviewed journals and presentations in leading scientific conferences (ASMS, ACS, etc.).

Preferred Experience and Skill Set:
•    Experience with automation platforms and their use for targeted protein quantitation workflows.
•    Proficiency in various bioinformatics tools such as PEAKS, Proteome Discoverer, MaxQuant, and database search engines.
•    Proficiency in one of the following languages or software packages:  python, javascript, Matlab, or R (preference for python), Unix/linux OS experience.
•    Familiarity of discovery proteomics in biomarkers research.
 

Who we are …

We are known as Merck & Co., Inc., Kenilworth, New Jersey, USA in the United States and Canada and MSD everywhere else. For more than a century, we have been inventing for life, bringing forward medicines and vaccines for many of the world's most challenging diseases. Today, our company continues to be at the forefront of research to deliver innovative health solutions and advance the prevention and treatment of diseases that threaten people and animals around the world.

What we look for …

In a world of rapid innovation, we seek brave Inventors who want to make an Impact in all aspects of our business, enabling breakthroughs that will affect generations to come. We encourage you to bring your disruptive thinking, collaborative spirit and diverse perspective to our organization. Together we will continue Inventing For Life, Impacting Lives while Inspiring Your Career Growth.

Invent. Impact. Inspire.

NOTICE FOR INTERNAL APPLICANTS

In accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.

If you have been offered a separation benefits package, but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separation package, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor

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We are proud to be a company that embraces the value of bringing diverse, talented, and committed people together. The fastest way to breakthrough innovation is when diverse ideas come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively. We are an equal opportunity employer, committed to fostering an inclusive and diverse workplace.

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Merck & Co., Inc., Kenilworth, NJ, USA, also known as Merck Sharp & Dohme Corp., Kenilworth, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

Employee Status:

Regular

Relocation:

Domestic

VISA Sponsorship:

Yes

Travel Requirements:

10%

Flexible Work Arrangements:

Not Specified

Shift:

Valid Driving License:

Hazardous Material(s):

Number of Openings:

2

Requisition ID:R119632

West Point, Pennsylvania

Today's Merck is a global healthcare leader working to help the world be well. Merck is known as MSD outside the United States and Canada. Through our prescription medicines, vaccines, biologic therapies, and consumer care and animal health products, we work with customers and operate in more than 140 countries to deliver innovative health solutions. We also demonstrate our commitment to increasing access to healthcare through far-reaching policies, programs and partnerships. For more information, visit www.merck.com.

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