Postdoctoral Research Fellow – Oral Delivery of Biologics for Precision Medicine - Military Veterans

at Merck & Company

Kenilworth, New Jersey

Job Description

Be a part of the legacy: Postdoctoral Research Fellow Program

Our Research Laboratories’ Postdoctoral Research Fellow Program aims to be a best-in-industry program for industrial postdoctoral researchers, designed to provide you with an academic focus in a commercial environment. With the resources, reach, and expertise of a large pharmaceutical company, postdoctoral researchers will be positioned to excel in an institution committed to breakthrough innovation in research and discovery.

What You'll Be Doing:

As a Postdoctoral Research Fellow within the Pharmaceutical Sciences organization, you will work with a highly collaborative, multidisciplinary team to develop a versatile biomaterials platform to enable the oral administration of structurally diverse large molecule APIs (therapeutic proteins, peptides, antigens) with enhanced bioavailability and pharmacokinetic properties.  In this laboratory-based role, you will design and assess of a variety of formulation approaches with specific focus on the relationship between physical and biochemical properties to transepithelial transport and the role of local and systemic delivery on therapeutic response. You'll also assess strategies for targeting gastrointestinal regions (such as stomach, small bowel, and colon-cell populations) and internalization pathways.

In this role, you will have the opportunity to interact with various experts across the Company network, present at scientific forums (both internally and externally), and publish novel findings in peer-reviewed manuscripts.  You are expected to work closely together with fellow researchers in our team, but should also be capable of independently developing and implementing their own ideas and strategy.  You should be a passionate scientist with strong academic fundamentals and a drive to develop new medicines to improve human health. 

Responsibilities include but are not limited to:

  • Design, develop, and execute studies to enable the oral delivery of structurally diverse large molecule APIs (therapeutic proteins, peptides, antigens)

  • Lead the design, synthesis and biophysical characterization of both targeted and non-targeted formulation approaches to enhance absorption and reduce variability of drug exposure

  • Support evaluation of formulations including assessment of binding strength / kinetics, drug release kinetics, and stability of released API structure and function under different stress conditions

  • Assess in vitro and ex vivo models to characterize intestinal absorption and epithelial transport mechanisms, and use the data obtained to aid predictive modeling of in situ absorption

  • Develop bioconjugation strategies and interrogate the relationship to transport efficiency 

  • Advance research findings into preclinical assessment, including the design and execution of in vivo studies to characterize efficacy and safety (PK/PD, tolerability, and biodistribution)

  • Interpret data and present results for team / senior management discussions and at scientific forums (both internally and externally)

  • Lead the authoring of literature reviews and manuscript preparation of research findings for peer-reviewed journals

What You Need:

  • Candidates must currently hold a PhD OR receive a PhD by fall of 2021. Degree should be in Pharmaceutical Sciences / Pharmaceutics, Chemical Engineering, Chemistry, Biomedical Engineering, Materials Science and Engineering, Biology, or related discipline

  • Background in biomaterials, polymer chemistry, and/or bioconjugation strategies

  • Knowledge and skills in analytical characterization

  • Demonstrated strong history of publication in peer-reviewed journals

It's Great If You Have:

  • Strong scientific acumen, with ability to solve problems of medium/high complexity via independent planning, design, execution, and interpretation of experiments

  • Experimental knowledge and skills in formulation or drug delivery technologies.  Experience with particle-based delivery systems is a plus. 

  • Experimental knowledge and skills in bioanalytical characterization of large molecules. Experience in characterization of binding strength / kinetics is a plus.

  • Knowledge and skills in cell culture and executing in vitro cell based assays

  • Knowledge and capability of executing studies to characterize intestinal absorption and epithelial transport mechanisms.  Experience with in vitro models of intestinal and colonic epithelium is a plus.  Knowledge and capability of executing in vivo studies is a plus.

  • Experience in all or some of the following methods: 

    • Materials Characterization: NMR, Fourier-transform infrared spectroscopy (FTIR), dynamic light scattering (DLS), differential scanning calorimetry (DSC), SEC, imaging techniques (TEM/SEM), rheology, high pressure liquid chromatography

    • Biophysical Characterization: ELISA, SDS-PAGE, circular dichroism (CD), surface plasmon resonance (SPR), fluorescence spectroscopy, in vitro TEER

  • Be energetic, enthusiastic and self-motivated, with a strong desire to learn and contribute

We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we “follow the science” and that great medicines can make a significant impact to our world. And we believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe.

Who we are …

We are known as Merck & Co., Inc., Kenilworth, New Jersey, USA in the United States and Canada and MSD everywhere else. For more than a century, we have been inventing for life, bringing forward medicines and vaccines for many of the world's most challenging diseases. Today, our company continues to be at the forefront of research to deliver innovative health solutions and advance the prevention and treatment of diseases that threaten people and animals around the world.

What we look for …

In a world of rapid innovation, we seek brave Inventors who want to make an Impact in all aspects of our business, enabling breakthroughs that will affect generations to come. We encourage you to bring your disruptive thinking, collaborative spirit and diverse perspective to our organization. Together we will continue Inventing For Life, Impacting Lives while Inspiring Your Career Growth.

INVENT.

IMPACT.

INSPIRE.

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US and Puerto Rico Residents Only:

If you need an accommodation for the application process please email us at staffingaadar@msd.com
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We are an equal opportunity employer, Minority/Female/Disability/Veteran – proudly embracing diversity in all of its manifestations.

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Employee Status:

Regular

Relocation:

Domestic/International

VISA Sponsorship:

Yes

Travel Requirements:

Flexible Work Arrangements:

Shift:

Valid Driving License:

Hazardous Material(s):

Number of Openings:

1

Requisition ID:R94272

Kenilworth, New Jersey

Today's Merck is a global healthcare leader working to help the world be well. Merck is known as MSD outside the United States and Canada. Through our prescription medicines, vaccines, biologic therapies, and consumer care and animal health products, we work with customers and operate in more than 140 countries to deliver innovative health solutions. We also demonstrate our commitment to increasing access to healthcare through far-reaching policies, programs and partnerships. For more information, visit www.merck.com.