St. Louis, Missouri

EOE Statement: Washington University is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, age, sex, sexual orientation, gender identity or expression, national origin, genetic information, disability, or protected veteran status. Job Type/Schedule: This position is full-time and works approximately 40 hours per week. Department Name/Job Location: This position is in the Department of Surgery.  This position is for the Medical School Campus. Essential Functions: POSITION SUMMARY: This position affords the exciting opportunity to be part of a new and rapidly growing collaborative research effort in the laboratory between the Eghtesady lab and the Wylie lab aimed at analyzing the maternal virome, antibody repertoire, and possible HLA predispositions in causation of CHD, a novel and exciting area of investigation.  While a significant portion of the research endeavor is focused on analysis of select cardiotropic viruses, there is interest in the broader virome and possible new pathogen. The work studies these mechanisms across a diverse disease landscape affecting pregnancy with particular emphasis currently on diabetes. The Eghtesady lab has expertise in several relevant animal models, virology assays and cardiac chamber-specific knockout models which will be important for success in this project. The Wylie lab applies ViroCap capture techniques in combination with NGS and high-throughput screening and selection methods to identify potential novel viruses. Together they aim to identify new pathways of CHD pathogenesis, as well as better understand the interplay between the maternal immune response and the fetus. This position assists in developing and conducting research projects, including experimental design, data analysis and documentation of experimental results. PRIMARY DUTIES AND RESPONSIBILITIES: Following instructions and discussions with the principal investigator, designs research protocols, including developing procedures for the collection, verification and management of data. The successful candidate will have the primary responsibility of driving the development and implementation of animal models, analysis of biorepository samples, and progress of the experiments.  Assists with grant preparation and reporting. They will work closely with project PIs, project coordinators, staff scientists, and trainees to ensure the success of the projects and will prepare and present data and progress reports in joint team meetings and to funding agencies.  Performs statistical analysis of data collected and writes interpretative reports. Verifies the correctness of the data submitted and makes recommendations based on these analyses. Documents research topics and prepares and submits papers based on research work to publications and committees for publication or presentation to peers.  Solves practical problems relating to difficulties with equipment or test subjects. Suggests technical or procedural improvements in testing methods. Conducts literature searches related to research project. Closely mentors one or more research associates and assists them with troubleshooting and optimizing experiments. Required Qualifications: Master’s degree with four years of experience in research lab operations or an equivalent combination of education and experience equaling nine years. Preferred Qualifications: Ph.D. degree or foreign equivalent in biomedical/cell/molecular biology or related fields. Minimum of two years of postdoctoral training with relevant experience in a biological research laboratory. Demonstrated success executing projects involving cellular and animal models of disease. Demonstrated ability to be highly productive in a fluid, fast-paced and collaborative work environment. Background in developmental biology, cardiac development, or virology. Experience developing and/or applying disease/cellular/in vivo models. First-hand experience in small animal surgeries, cellular assay development, and CRISPR/Transgenic/KO or other equivalent genetically modified animal models. Exceptional written and oral communication skills Outstanding interpersonal and leadership skills. Salary Range: The hiring range for this position is $46,779 - $63,170 annually. Pre-Employment Screening: All external candidates receiving an offer for employment will be required to submit to pre-employment screening for this position. Current employees applying for a new position within the university may be subject to this requirement. The screenings will include a criminal background check and, as applicable for the position, other background checks, drug screen, employment and education or licensure/certification verification, physical examination, certain vaccinations and/or governmental registry checks. All offers are contingent upon successful completion of required screening. Benefits: This position is eligible for full-time benefits.  Please click the following link to view a summary of benefits:   https://wustl.box.com/s/8wkhs25yssf0775x9d6nd6vqa7obpth7 . Applicant Special Instructions: WORKING CONDITIONS: This position works in a laboratory environment with potential exposure to biological and chemical hazards.  The individual must be physically able to wear protective equipment and to provide standard care to research animals. Internal Applicant Instruction: This position is grade R10. Please attach a copy of your most current signed performance evaluation (completed within the last 18 months) to your online account.  If you have not received a performance evaluation, you may provide two current signed letters of recommendation (written within the last 18 months), preferably to include one letter from either a current or recent former supervisor.  To attach these documents, go to:  My Career Tools, Add Attachment, Attachment Type – Performance Reviews or Letters of Recommendation. Department Summary: The CHD (Congenital Heart Diseases) Research Laboratory, part of the world-renown Department of Surgery at Washington University in St. Louis is looking for an exceptional research scientist candidate to lead a new innovative project with special emphasis on role of viruses in congenital heart diseases (CHD). The department ranks among the top U.S. academic surgery departments in annual NIH, non-federal and corporate-supported grants. The laboratory also benefits from support by St Louis Children’s Hospital, one of the premier children's hospitals in the United States, serving not just children of St. Louis, but children from across the world. As the pediatric teaching hospital for Washington University School of Medicine, the hospital offers nationally recognized programs for physician training and research.