Rahway, New Jersey

Job Description

The Protein Engineering group in Rahway, New Jersey is seeking a Principal Scientist to join our group and expand our capabilities in the design and engineering of proteins with novel functions.  The mission of the group is to engineer enzymes for use as biocatalysts to synthesize APIs and to engineer proteins and peptides as therapeutics. We view protein engineering as a key enabling technology in modern drug discovery and development.  We leverage computational modeling, advanced automation, and high-throughput screening to engineer novel proteins.  We are committed to developing new methodologies and technologies that enhance protein engineering and improve human health. 

In this role, the incumbent will help to define the group’s strategy and lead teams of scientists working across our company (Process Chemistry, Discovery Chemistry, Analytical Chemistry, Biologics, and Vaccines) to engineer novel proteins. They will lead teams focused on the engineering of therapeutic proteins, peptides, and enzymes to improve their biophysical properties, production, and efficacy.  Working collaboratively with our partner groups, they will identify high impact cross-functional projects to enhance our company's pipeline. As a project leader, they will set priorities and goals for their teams and work side-by-side with them in the lab.  Using their experience in biotherapeutic drug discovery and development, they will help to identify, develop, and implement novel protein engineering technologies to enhance our ability to engineer difficult targets.  As a senior leader in the group, they will mentor, coach, and train scientists at the bench. The successful candidate will join a diverse group of innovative scientists who are driving the next revolution in bioengineering.


    • Experience and knowledge in the development (upstream and/or downstream), characterization (PK/PD, biophysics, biochemistry), or engineering of biotherapeutics.

    • Experience with a range of recombinant host organisms.

    • Experience with biochemical and/or phenotypic assays for protein function.

    • Demonstrated ability to lead collaborative multi-disciplinary teams to successful outcomes.

    • Demonstrated ability to coach and mentor talent.

    • Excellent communication and organizational skills.

    Education Minimum Requirements

    • Ph.D. in Chemistry, Biochemistry, Biophysics, Molecular Biology, Bioengineering, Synthetic Biology or a related field with 6+ years of industry experience.

    We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we “follow the science” that great medicines can make a significant impact to our world. We believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe. 

    Who we are …

    We are known as Merck & Co., Inc., Kenilworth, New Jersey, USA in the United States and Canada and MSD everywhere else. For more than a century, we have been inventing for life, bringing forward medicines and vaccines for many of the world's most challenging diseases. Today, our company continues to be at the forefront of research to deliver innovative health solutions and advance the prevention and treatment of diseases that threaten people and animals around the world.

    What we look for …

    In a world of rapid innovation, we seek brave Inventors who want to make an Impact in all aspects of our business, enabling breakthroughs that will affect generations to come. We encourage you to bring your disruptive thinking, collaborative spirit and diverse perspective to our organization. Together we will continue Inventing For Life, Impacting Lives while Inspiring Your Career Growth.





    In accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.

    If you have been offered a separation benefits package, but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separation package, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor.

    US and Puerto Rico Residents Only:

    If you need an accommodation for the application process please email us at staffingaadar@msd.com
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    We are an equal opportunity employer, Minority/Female/Disability/Veteran – proudly embracing diversity in all of its manifestations.

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    Merck & Co., Inc., Kenilworth, NJ, USA, also known as Merck Sharp & Dohme Corp., Kenilworth, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

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    Requisition ID:R83369

    Rahway, New Jersey

    Today's Merck is a global healthcare leader working to help the world be well. Merck is known as MSD outside the United States and Canada. Through our prescription medicines, vaccines, biologic therapies, and consumer care and animal health products, we work with customers and operate in more than 140 countries to deliver innovative health solutions. We also demonstrate our commitment to increasing access to healthcare through far-reaching policies, programs and partnerships. For more information, visit www.merck.com.

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